Gastric pyloric gland adenoma

a multicentre clinicopathological study of 67 cases

Won Tak Choi, Ian Brown, Tetsuo Ushiku, Masato Yozu, Namrata Setia, Amitabh Srivastava, Melanie Johncilla, Rish Pai, Ryan M. Gill, Masashi Fukayama, Joseph Misdraji, Gregory Y. Lauwers

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aims: There is limited information regarding the clinicopathological and immunohistochemical characteristics of gastric pyloric gland adenomas (PGAs). Methods and results: Sixty-seven cases of gastric PGA from 57 patients were analysed. PGAs occurred with similar frequency in men and women (47.4 and 52.6%, respectively), with a mean age of 66 years. Most presented in the gastric body/fundus (67.2%). Fifteen cases (22.4%) developed against a background of autoimmune gastritis (AIG), whereas normal mucosa was seen in 35.8%. Only 16.4% (11 cases) developed in patients with a genetic predisposition, most commonly familial adenomatous polyposis. Low-grade lesions had a mean size of 1.5 cm, while PGAs with high-grade dysplasia (HGD) or adenocarcinoma had a mean size of 3.5 cm (P < 0.001) and more commonly showed tubulovillous architecture (50.0 versus 25.6% in low-grade dysplasia; P = 0.040). Most PGAs (61.2%) co-expressed mucin (MUC)5AC and MUC6 (mixed type), which was associated significantly with HGD or adenocarcinoma (P = 0.013). AIG was also associated with HGD (P = 0.027), but genetic predisposition did not correlate with the grade of dysplasia (P = 0.793). The recurrence rate of PGA was similar for high- (11.8%) and low-grade lesions (7.4%) (P = 0.624). Conclusions: The risk of HGD increases with the size of PGA, tubulovillous architecture and the presence of AIG as well as mixed immunophenotype. As the overall local recurrence rate is less than 10%, PGAs may be treated conservatively, but they should be excised completely if possible, particularly if they are large or show high-grade features.

Original languageEnglish (US)
Pages (from-to)1007-1014
Number of pages8
JournalHistopathology
Volume72
Issue number6
DOIs
StatePublished - May 1 2018

Fingerprint

Gastric Mucosa
Adenoma
Multicenter Studies
Gastritis
Genetic Predisposition to Disease
Mucin 5AC
Adenocarcinoma
Gastric Fundus
Recurrence
Adenomatous Polyposis Coli
Mucous Membrane

Keywords

  • autoimmune gastritis
  • dysplasia
  • pyloric gland adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Choi, W. T., Brown, I., Ushiku, T., Yozu, M., Setia, N., Srivastava, A., ... Lauwers, G. Y. (2018). Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology, 72(6), 1007-1014. https://doi.org/10.1111/his.13460

Gastric pyloric gland adenoma : a multicentre clinicopathological study of 67 cases. / Choi, Won Tak; Brown, Ian; Ushiku, Tetsuo; Yozu, Masato; Setia, Namrata; Srivastava, Amitabh; Johncilla, Melanie; Pai, Rish; Gill, Ryan M.; Fukayama, Masashi; Misdraji, Joseph; Lauwers, Gregory Y.

In: Histopathology, Vol. 72, No. 6, 01.05.2018, p. 1007-1014.

Research output: Contribution to journalArticle

Choi, WT, Brown, I, Ushiku, T, Yozu, M, Setia, N, Srivastava, A, Johncilla, M, Pai, R, Gill, RM, Fukayama, M, Misdraji, J & Lauwers, GY 2018, 'Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases', Histopathology, vol. 72, no. 6, pp. 1007-1014. https://doi.org/10.1111/his.13460
Choi WT, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A et al. Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology. 2018 May 1;72(6):1007-1014. https://doi.org/10.1111/his.13460
Choi, Won Tak ; Brown, Ian ; Ushiku, Tetsuo ; Yozu, Masato ; Setia, Namrata ; Srivastava, Amitabh ; Johncilla, Melanie ; Pai, Rish ; Gill, Ryan M. ; Fukayama, Masashi ; Misdraji, Joseph ; Lauwers, Gregory Y. / Gastric pyloric gland adenoma : a multicentre clinicopathological study of 67 cases. In: Histopathology. 2018 ; Vol. 72, No. 6. pp. 1007-1014.
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abstract = "Aims: There is limited information regarding the clinicopathological and immunohistochemical characteristics of gastric pyloric gland adenomas (PGAs). Methods and results: Sixty-seven cases of gastric PGA from 57 patients were analysed. PGAs occurred with similar frequency in men and women (47.4 and 52.6{\%}, respectively), with a mean age of 66 years. Most presented in the gastric body/fundus (67.2{\%}). Fifteen cases (22.4{\%}) developed against a background of autoimmune gastritis (AIG), whereas normal mucosa was seen in 35.8{\%}. Only 16.4{\%} (11 cases) developed in patients with a genetic predisposition, most commonly familial adenomatous polyposis. Low-grade lesions had a mean size of 1.5 cm, while PGAs with high-grade dysplasia (HGD) or adenocarcinoma had a mean size of 3.5 cm (P < 0.001) and more commonly showed tubulovillous architecture (50.0 versus 25.6{\%} in low-grade dysplasia; P = 0.040). Most PGAs (61.2{\%}) co-expressed mucin (MUC)5AC and MUC6 (mixed type), which was associated significantly with HGD or adenocarcinoma (P = 0.013). AIG was also associated with HGD (P = 0.027), but genetic predisposition did not correlate with the grade of dysplasia (P = 0.793). The recurrence rate of PGA was similar for high- (11.8{\%}) and low-grade lesions (7.4{\%}) (P = 0.624). Conclusions: The risk of HGD increases with the size of PGA, tubulovillous architecture and the presence of AIG as well as mixed immunophenotype. As the overall local recurrence rate is less than 10{\%}, PGAs may be treated conservatively, but they should be excised completely if possible, particularly if they are large or show high-grade features.",
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