Gastric endoscopic remodeling techniques

The stomach has been an obvious target for endoscopic remodeling to facilitate weight loss. Success is shaped by many challenges that must be addressed. The key challenges include mimicking or improving upon existing (permanent) surgical therapies, recognizing the body's response to foreign objects and materials, and understanding the neurenteric pathway as it relates to meals, hunger, satiation, and satiety. Early remodeling efforts failed because of technical limitations and limited understanding of the physiology of weight loss applied to the stomach. Current methods, especially the endoscopic sleeve gastroplasty, use improved technology and continue to be modeled on ongoing research into the physiology of changes made within the stomach.