Gas exchange during exercise in habitually active asthmatic subjects

H. C. Haverkamp, J. A. Dempsey, Jordan D Miller, L. M. Romer, D. F. Pegelow, J. M. Modman, M. W. Eldridge

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We determined the relations among gas exchange, breathing mechanics, and airway inflammation during moderate- to maximum-intensity exercise in asthmatic subjects. Twenty-one habitually active (48.2 ± 7.0 ml· kg -1·min -1 maximal O 2 uptake) mildly to moderately asthmatic subjects (94 ± 13% predicted forced expiratory volume in 1.0 s) performed treadmill exercise to exhaustion (11.2 ± 0.15 min) at ∼90% of maximal O 2 uptake. Arterial O 2 saturation decreased to ≤94% during the exercise in 8 of 21 subjects, in large part as a result of a decrease in arterial Po 2 (Pao 2): from 93.0 ± 7.7 to 79.7 ± 4.0 Torr. A widened alveolar-to-arterial Po 2 difference and the magnitude of the ventilatory response contributed approximately equally to the decrease in PaO 2, during exercise. Airflow limitation and airway inflammation at baseline did not correlate with exercise gas exchange, but an exercise-induced increase in sputum histamine levels correlated with exercise Pao 2 (negatively) and alveolar-to-arterial Po 2 difference (positively). Mean pulmonary resistance was high during exercise (3.4 ± 1.2 CmH 2O·I -1·S) and did not increase throughout exercise. Expiratory flow limitation occurred in 19 of 21 subjects, averaging 43 ± 35% of tidal volume near end exercise, and end-expiratory lung volume rose progressively to 0.25 ± 0.47 liter greater than resting end-expiratory lung volume at exhaustion. These mechanical constraints to ventilation contributed to a heterogeneous and frequently insufficient ventilatory response; arterial PcO 2 was 30-47 Torr at end exercise. Thus pulmonary gas exchange is impaired during high-intensity exercise in a significant number of habitually active asthmatic subjects because of high airway resistance and, possibly, a deleterious effect of exercise-induced airway inflammation on gas exchange efficiency.

Original languageEnglish (US)
Pages (from-to)1938-1950
Number of pages13
JournalJournal of Applied Physiology
Volume99
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Gases
Inflammation
Lung
Pulmonary Gas Exchange
Respiratory Mechanics
Airway Resistance
Tidal Volume
Forced Expiratory Volume
Sputum
Histamine
Ventilation

Keywords

  • Airway inflammation
  • Exercise hyperventilation
  • Exercise-induced arterial hypoxemia
  • Induced sputum
  • Prolonged exercise

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Haverkamp, H. C., Dempsey, J. A., Miller, J. D., Romer, L. M., Pegelow, D. F., Modman, J. M., & Eldridge, M. W. (2005). Gas exchange during exercise in habitually active asthmatic subjects. Journal of Applied Physiology, 99(5), 1938-1950. https://doi.org/10.1152/japplphysiol.00041.2005

Gas exchange during exercise in habitually active asthmatic subjects. / Haverkamp, H. C.; Dempsey, J. A.; Miller, Jordan D; Romer, L. M.; Pegelow, D. F.; Modman, J. M.; Eldridge, M. W.

In: Journal of Applied Physiology, Vol. 99, No. 5, 11.2005, p. 1938-1950.

Research output: Contribution to journalArticle

Haverkamp, HC, Dempsey, JA, Miller, JD, Romer, LM, Pegelow, DF, Modman, JM & Eldridge, MW 2005, 'Gas exchange during exercise in habitually active asthmatic subjects', Journal of Applied Physiology, vol. 99, no. 5, pp. 1938-1950. https://doi.org/10.1152/japplphysiol.00041.2005
Haverkamp HC, Dempsey JA, Miller JD, Romer LM, Pegelow DF, Modman JM et al. Gas exchange during exercise in habitually active asthmatic subjects. Journal of Applied Physiology. 2005 Nov;99(5):1938-1950. https://doi.org/10.1152/japplphysiol.00041.2005
Haverkamp, H. C. ; Dempsey, J. A. ; Miller, Jordan D ; Romer, L. M. ; Pegelow, D. F. ; Modman, J. M. ; Eldridge, M. W. / Gas exchange during exercise in habitually active asthmatic subjects. In: Journal of Applied Physiology. 2005 ; Vol. 99, No. 5. pp. 1938-1950.
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