Future directions in idiopathic pulmonary fibrosis research an NHLBI workshop report

Timothy S. Blackwell, Andrew M. Tager, Zea Borok, Bethany B. Moore, David A. Schwartz, Kevin J. Anstrom, Ziv Bar-Joseph, Peter Bitterman, Michael R. Blackburn, William Bradford, Kevin K. Brown, Harold A. Chapman, Harold R. Collard, Gregory P. Cosgrove, Robin Deterding, Ramona Doyle, Kevin R. Flaherty, Christine Kim Garcia, James S. Hagood, Craig A. HenkeErica Herzog, Cory M. Hogaboam, Jeffrey C. Horowitz, Talmadge E. King, James E. Loyd, William E. Lawson, Clay B. Marsh, Paul W. Noble, Imre Noth, Dean Sheppard, Julie Olsson, Luis A. Ortiz, Thomas G. O'Riordan, Tim D. Oury, Ganesh Raghu, Jesse Roman, Patricia J. Sime, Thomas H. Sisson, Daniel Tschumperlin, Shelia M. Violette, Timothy E. Weaver, Rebecca G. Wells, Eric S. White, Naftali Kaminski, Fernando J. Martinez, Thomas A. Wynn, Victor J. Thannickal, Jerry P. Eu

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

The median survival of patients with idiopathic pulmonary fibrosis (IPF) continues to be approximately 3 years from the time of diagnosis, underscoring the lack of effective medical therapies for this disease. In the United States alone, approximately 40,000 patients die of this disease annually. In November 2012, the NHLBI held a workshop aimed at coordinating research efforts and accelerating the development of IPF therapies. Basic, translational, and clinical researchers gathered with representatives from the NHLBI, patient advocacy groups, pharmaceutical companies, and the U.S. Food and Drug Administration to review the current state of IPF research and identify priority areas, opportunities for collaborations, and directions for future research. The workshop was organized into groups that were tasked with assessing and making recommendations to promote progress in one of the following six critical areas of research: (1) biology of alveolar epithelial injury and aberrant repair; (2) role of extracellular matrix; (3) preclinical modeling; (4) role of inflammation and immunity; (5) genetic, epigenetic, and environmental determinants; (6) translation of discoveries into diagnostics and therapeutics. The workshop recommendations provide a basis for directing future research and strategic planning by scientific, professional, and patient communities and the NHLBI.

Original languageEnglish (US)
Pages (from-to)214-222
Number of pages9
JournalAmerican journal of respiratory and critical care medicine
Volume189
Issue number2
DOIs
StatePublished - Jan 15 2014

Keywords

  • Alveolar epithelial cells
  • Extracellular matrix
  • Idiopathic pulmonary fibrosis
  • Inflammation
  • Interstitial lung disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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  • Cite this

    Blackwell, T. S., Tager, A. M., Borok, Z., Moore, B. B., Schwartz, D. A., Anstrom, K. J., Bar-Joseph, Z., Bitterman, P., Blackburn, M. R., Bradford, W., Brown, K. K., Chapman, H. A., Collard, H. R., Cosgrove, G. P., Deterding, R., Doyle, R., Flaherty, K. R., Garcia, C. K., Hagood, J. S., ... Eu, J. P. (2014). Future directions in idiopathic pulmonary fibrosis research an NHLBI workshop report. American journal of respiratory and critical care medicine, 189(2), 214-222. https://doi.org/10.1164/rccm.201306-1141WS