Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues

Xiaoke Wang; Renata Q. Zamolyi; Hongying Zhang; Vera L. Pannain; Fabiola Medeiros; Michele Erickson-Johnson; Robert B. Jenkins; Andre M. Oliveira

doi:10.1016/j.cancergencyto.2009.09.003

Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues

Xiaoke Wang, Renata Q. Zamolyi, Hongying Zhang, Vera L. Pannain, Fabiola Medeiros, Michele Erickson-Johnson, Robert B. Jenkins, Andre M. Oliveira

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2, but has not been seen fused to HMGA1. We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2-LPP in tumorigenesis.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	196
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.09.003
State	Published - Jan 1 2010

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2009.09.003

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@article{8a388ecdebb44285a8438c4ac0d876af,

title = "Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues",

abstract = "Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2, but has not been seen fused to HMGA1. We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2-LPP in tumorigenesis.",

author = "Xiaoke Wang and Zamolyi, {Renata Q.} and Hongying Zhang and Pannain, {Vera L.} and Fabiola Medeiros and Michele Erickson-Johnson and Jenkins, {Robert B.} and Oliveira, {Andre M.}",

note = "Funding Information: This work was funded by Fraternal Order of Eagles Foundation Award 237 and Mayo Clinic CR20 Award 14546. ",

year = "2010",

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doi = "10.1016/j.cancergencyto.2009.09.003",

language = "English (US)",

volume = "196",

pages = "64--67",

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T1 - Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues

AU - Wang, Xiaoke

AU - Zamolyi, Renata Q.

AU - Zhang, Hongying

AU - Pannain, Vera L.

AU - Medeiros, Fabiola

AU - Erickson-Johnson, Michele

AU - Jenkins, Robert B.

AU - Oliveira, Andre M.

N1 - Funding Information: This work was funded by Fraternal Order of Eagles Foundation Award 237 and Mayo Clinic CR20 Award 14546.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2, but has not been seen fused to HMGA1. We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2-LPP in tumorigenesis.

AB - Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2, but has not been seen fused to HMGA1. We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2-LPP in tumorigenesis.

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DO - 10.1016/j.cancergencyto.2009.09.003

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AN - SCOPUS:70949093528

SN - 0165-4608

VL - 196

SP - 64

EP - 67

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues

Abstract

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