Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues

Xiaoke Wang, Renata Q. Zamolyi, Hongying Zhang, Vera L. Pannain, Fabiola Medeiros, Michele Erickson-Johnson, Robert Brian Jenkins, Andre M. Oliveira

Research output: Contribution to journalArticle

10 Scopus citations


Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2, but has not been seen fused to HMGA1. We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2-LPP in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Jan 1 2010


ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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