Functional measurement of respiratory muscle motor behaviors using transdiaphragmatic pressure

Sarah M. Greising; Carlos Bernardo Mantilla; Gary C Sieck

doi:10.1007/978-1-4939-3810-0_21

Functional measurement of respiratory muscle motor behaviors using transdiaphragmatic pressure

Sarah M. Greising, Carlos Bernardo Mantilla, Gary C Sieck

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

The diaphragm muscle must be able to generate sufficient forces to accomplish a range of ventilatory and non-ventilatory behaviors throughout life. Measurements of transdiaphragmatic pressure (Pdi) can be conducted during eupnea, hypoxia (10 % O₂)-hypercapnia (5 % CO₂), chemical airway stimulation (i.e., sneezing), spontaneously occurring deep breaths (i.e., sighs), sustained airway or tracheal occlusion, and maximal efforts elicited via bilateral phrenic nerve stimulation, representing the full range of motor behaviors available by the diaphragm muscle. We provide detailed methods on the in vivo measurements of Pdi in mice.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	309-319
Number of pages	11
Volume	1460
DOIs	https://doi.org/10.1007/978-1-4939-3810-0_21
State	Published - Aug 6 2016

Publication series

Name	Methods in Molecular Biology
Volume	1460
ISSN (Print)	10643745

Keywords

Diaphragm muscle
Mouse
Muscle force
Non-ventilatory behavior
Phrenic nerve
Ventilatory behavior

ASJC Scopus subject areas

Medicine(all)
Molecular Biology
Genetics

Access to Document

10.1007/978-1-4939-3810-0_21

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Greising, S. M., Mantilla, C. B., & Sieck, G. C. (2016). Functional measurement of respiratory muscle motor behaviors using transdiaphragmatic pressure. In Methods in Molecular Biology (Vol. 1460, pp. 309-319). (Methods in Molecular Biology; Vol. 1460). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3810-0_21

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