Functional interrelationships between nuclear structure and transcriptional control: Contributions to regulation of cell cycle- and tissue- specific gene expression

Gary S. Stein, Janet L. Stein, Jane B. Lian, André J. Van Wijnen, Martin Montecino

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue- specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.

Original languageEnglish (US)
Pages (from-to)198-209
Number of pages12
JournalJournal of cellular biochemistry
Volume62
Issue number2
DOIs
StatePublished - Aug 1996

Keywords

  • cell cycle
  • gene regulatory sequences
  • nuclear structure
  • tissue-related signals
  • transcriptional control

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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