Functional Gall-Bladder and Sphincter of Oddi Disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Functional disorders of the biliary tree include gallbladder dyskinesia and Sphincter of Oddi dysfunction. Both present as recurrent epigastric and right upper quadrant pain reminiscent of biliary colic, in the absence of biliary stones. Gallbladder dyskinesia is defined by an ejection fraction below 35% following slow infusion of a weight based dose of CCK. The pathogenesis of pain is unclear; never-the-less, cholecystectomy is the therapy of choice. Data are mixed as to whether subnormal gallbladder emptying predicts improvement following surgery in patients with pain of suspected biliary origin. Sphincter of Oddi dysfunction is defined as pain related to fixed or dynamic obstruction of the biliary or pancreatic ducts. It is commonly characterized by whether it involves the biliary and/or the pancreatic sphincter and by the presence or absence of objective abnormalities of bile duct or pancreatic duct caliber or by abnormalities of serum liver or pancreatic enzymes during pain. Diagnosis is classically made by manometric identification of basal sphincter pressures over 40 mm Hg during endoscopic retrograde cholangiopancreatography (ERCP). SOD is treated by endoscopic sphincterotomy of the hypertensive sphincter(s). Prophylactic pancreatic stent placement is employed to reduce the risk of procedure induced pancreatitis.

Original languageEnglish (US)
Title of host publicationPractical Gastroenterology and Hepatology: Liver and Biliary Disease
PublisherWiley-Blackwell
Pages365-373
Number of pages9
ISBN (Print)9781405182751
DOIs
StatePublished - Aug 31 2010

Fingerprint

Sphincter of Oddi
Urinary Bladder
Pain
Biliary Dyskinesia
Sphincter of Oddi Dysfunction
Pancreatic Ducts
Gallbladder Emptying
Endoscopic Sphincterotomy
Colic
Endoscopic Retrograde Cholangiopancreatography
Biliary Tract
Cholecystectomy
Bile Ducts
Pancreatitis
Stents
Pressure
Weights and Measures
Liver
Enzymes
Serum

Keywords

  • Cystic duct syndrome
  • Endoscopic manometry
  • Gall-bladder dyskinesia
  • Papillary stenosis
  • Post-cholecystectomy pain
  • Sphincter of Oddi dysfunction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Petersen, B. T. (2010). Functional Gall-Bladder and Sphincter of Oddi Disorders. In Practical Gastroenterology and Hepatology: Liver and Biliary Disease (pp. 365-373). Wiley-Blackwell. https://doi.org/10.1002/9781444325249.ch34

Functional Gall-Bladder and Sphincter of Oddi Disorders. / Petersen, Bret Thomas.

Practical Gastroenterology and Hepatology: Liver and Biliary Disease. Wiley-Blackwell, 2010. p. 365-373.

Research output: Chapter in Book/Report/Conference proceedingChapter

Petersen, BT 2010, Functional Gall-Bladder and Sphincter of Oddi Disorders. in Practical Gastroenterology and Hepatology: Liver and Biliary Disease. Wiley-Blackwell, pp. 365-373. https://doi.org/10.1002/9781444325249.ch34
Petersen BT. Functional Gall-Bladder and Sphincter of Oddi Disorders. In Practical Gastroenterology and Hepatology: Liver and Biliary Disease. Wiley-Blackwell. 2010. p. 365-373 https://doi.org/10.1002/9781444325249.ch34
Petersen, Bret Thomas. / Functional Gall-Bladder and Sphincter of Oddi Disorders. Practical Gastroenterology and Hepatology: Liver and Biliary Disease. Wiley-Blackwell, 2010. pp. 365-373
@inbook{e9bf27d54ebe4962935d1d8a531f651d,
title = "Functional Gall-Bladder and Sphincter of Oddi Disorders",
abstract = "Functional disorders of the biliary tree include gallbladder dyskinesia and Sphincter of Oddi dysfunction. Both present as recurrent epigastric and right upper quadrant pain reminiscent of biliary colic, in the absence of biliary stones. Gallbladder dyskinesia is defined by an ejection fraction below 35{\%} following slow infusion of a weight based dose of CCK. The pathogenesis of pain is unclear; never-the-less, cholecystectomy is the therapy of choice. Data are mixed as to whether subnormal gallbladder emptying predicts improvement following surgery in patients with pain of suspected biliary origin. Sphincter of Oddi dysfunction is defined as pain related to fixed or dynamic obstruction of the biliary or pancreatic ducts. It is commonly characterized by whether it involves the biliary and/or the pancreatic sphincter and by the presence or absence of objective abnormalities of bile duct or pancreatic duct caliber or by abnormalities of serum liver or pancreatic enzymes during pain. Diagnosis is classically made by manometric identification of basal sphincter pressures over 40 mm Hg during endoscopic retrograde cholangiopancreatography (ERCP). SOD is treated by endoscopic sphincterotomy of the hypertensive sphincter(s). Prophylactic pancreatic stent placement is employed to reduce the risk of procedure induced pancreatitis.",
keywords = "Cystic duct syndrome, Endoscopic manometry, Gall-bladder dyskinesia, Papillary stenosis, Post-cholecystectomy pain, Sphincter of Oddi dysfunction",
author = "Petersen, {Bret Thomas}",
year = "2010",
month = "8",
day = "31",
doi = "10.1002/9781444325249.ch34",
language = "English (US)",
isbn = "9781405182751",
pages = "365--373",
booktitle = "Practical Gastroenterology and Hepatology: Liver and Biliary Disease",
publisher = "Wiley-Blackwell",

}

TY - CHAP

T1 - Functional Gall-Bladder and Sphincter of Oddi Disorders

AU - Petersen, Bret Thomas

PY - 2010/8/31

Y1 - 2010/8/31

N2 - Functional disorders of the biliary tree include gallbladder dyskinesia and Sphincter of Oddi dysfunction. Both present as recurrent epigastric and right upper quadrant pain reminiscent of biliary colic, in the absence of biliary stones. Gallbladder dyskinesia is defined by an ejection fraction below 35% following slow infusion of a weight based dose of CCK. The pathogenesis of pain is unclear; never-the-less, cholecystectomy is the therapy of choice. Data are mixed as to whether subnormal gallbladder emptying predicts improvement following surgery in patients with pain of suspected biliary origin. Sphincter of Oddi dysfunction is defined as pain related to fixed or dynamic obstruction of the biliary or pancreatic ducts. It is commonly characterized by whether it involves the biliary and/or the pancreatic sphincter and by the presence or absence of objective abnormalities of bile duct or pancreatic duct caliber or by abnormalities of serum liver or pancreatic enzymes during pain. Diagnosis is classically made by manometric identification of basal sphincter pressures over 40 mm Hg during endoscopic retrograde cholangiopancreatography (ERCP). SOD is treated by endoscopic sphincterotomy of the hypertensive sphincter(s). Prophylactic pancreatic stent placement is employed to reduce the risk of procedure induced pancreatitis.

AB - Functional disorders of the biliary tree include gallbladder dyskinesia and Sphincter of Oddi dysfunction. Both present as recurrent epigastric and right upper quadrant pain reminiscent of biliary colic, in the absence of biliary stones. Gallbladder dyskinesia is defined by an ejection fraction below 35% following slow infusion of a weight based dose of CCK. The pathogenesis of pain is unclear; never-the-less, cholecystectomy is the therapy of choice. Data are mixed as to whether subnormal gallbladder emptying predicts improvement following surgery in patients with pain of suspected biliary origin. Sphincter of Oddi dysfunction is defined as pain related to fixed or dynamic obstruction of the biliary or pancreatic ducts. It is commonly characterized by whether it involves the biliary and/or the pancreatic sphincter and by the presence or absence of objective abnormalities of bile duct or pancreatic duct caliber or by abnormalities of serum liver or pancreatic enzymes during pain. Diagnosis is classically made by manometric identification of basal sphincter pressures over 40 mm Hg during endoscopic retrograde cholangiopancreatography (ERCP). SOD is treated by endoscopic sphincterotomy of the hypertensive sphincter(s). Prophylactic pancreatic stent placement is employed to reduce the risk of procedure induced pancreatitis.

KW - Cystic duct syndrome

KW - Endoscopic manometry

KW - Gall-bladder dyskinesia

KW - Papillary stenosis

KW - Post-cholecystectomy pain

KW - Sphincter of Oddi dysfunction

UR - http://www.scopus.com/inward/record.url?scp=84886068323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886068323&partnerID=8YFLogxK

U2 - 10.1002/9781444325249.ch34

DO - 10.1002/9781444325249.ch34

M3 - Chapter

AN - SCOPUS:84886068323

SN - 9781405182751

SP - 365

EP - 373

BT - Practical Gastroenterology and Hepatology: Liver and Biliary Disease

PB - Wiley-Blackwell

ER -