Fully-automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR

Christopher Schwarz, Evan Fletcher, Charles Decarli, Owen Carmichael

Research output: Chapter in Book/Report/Conference proceedingConference contribution

64 Scopus citations

Abstract

This paper presents a method for detection of cerebral white matter hyperintensities (WMH) based on run-time PD-, T1-, and T2-weighted structural magnetic resonance (MR) images of the brain along with labeled training examples. Unlike most prior approaches, the method is able to reliably detect WMHs in elderly brains in the absence of fluid-attenuated (FLAIR) images. Its success is due to the learning of probabilistic models of WMH spatial distribution and neighborhood dependencies from ground-truth examples of FLAIR-based WMH detections. These models are combined with a probabilistic model of the PD, T1, and T2 intensities of WMHs in a Markov Random Field (MRF) framework that provides the machinery for inferring the positions of WMHs in novel test images. The method is shown to accurately detect WMHs in a set of 114 elderly subjects from an academic dementia clinic. Experiments show that standard off-the-shelf MRF training and inference methods provide robust results, and that increasing the complexity of neighborhood dependency models does not necessarily help performance. The method is also shown to perform well when training and test data are drawn from distinct scanners and subject pools.

Original languageEnglish (US)
Title of host publicationInformation Processing in Medical Imaging - 21st International Conference, IPMI 2009, Proceedings
Pages239-251
Number of pages13
DOIs
StatePublished - 2009
Event21st International Conference on Information Processing in Medical Imaging, IPMI 2009 - Williamsburg, VA, United States
Duration: Jul 5 2009Jul 10 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5636 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference21st International Conference on Information Processing in Medical Imaging, IPMI 2009
CountryUnited States
CityWilliamsburg, VA
Period7/5/097/10/09

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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    Schwarz, C., Fletcher, E., Decarli, C., & Carmichael, O. (2009). Fully-automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR. In Information Processing in Medical Imaging - 21st International Conference, IPMI 2009, Proceedings (pp. 239-251). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5636 LNCS). https://doi.org/10.1007/978-3-642-02498-6_20