Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience

Mark T. Shiels, Albert J. Czaja, Howard F. Taswell, John L. Gerin, Robert H. Purcell, Jurgen Ludwig, Jorge Rakela, Cheryl A. Nelson

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Abstract

Of 560 hepatitis B surface antigen-positive patients who were tested for antibody to hepatitis δ-antigen by blocking radioimmunoassay, 29 (5%) were seropositive. Patients with chronic active hepatitis had a greater frequency of seropositivity than those with chronic persistent hepatitis (26% vs. 0%, p < 0.05), and patients with symptomatic chronic disease harbored the antibody more commonly than asymptomatic counterparts (14% vs. 2%, p < 0.01) or patients with acute hepatitis (14% vs. 1%, p < 0.02). Of 8 patients with acute fulminant hepatitis, including 6 who died of liver failure, none were seropositive. Antibody was detected in drug users, dialysis patients, hemophiliacs, and transfusion recipients; in 17 patients, however, including 3 homosexuals, it occurred sporadically. Samples harvested in 1969 contained δ-antibody. Antibody was found in most ethnic groups, including Orientals, where it occurred only in relocated Vietnamese. We conclude that δ-antibody is detected infrequently in a diverse referral population within the United States. Seropositivity is associated with symptomatic chronic disease and histologic findings of chronic active hepatitis. Homosexuals and resettled Vietnamese are susceptible to sporadic δ-infection.

Original languageEnglish (US)
Pages (from-to)1230-1234
Number of pages5
JournalGastroenterology
Volume89
Issue number6
StatePublished - 1985

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Chronic Hepatitis B
Antibodies
Chronic Hepatitis
Hepatitis
Chronic Disease
Hepatitis Antigens
Liver Failure
Hepatitis B Surface Antigens
Drug Users
Ethnic Groups
Radioimmunoassay
Dialysis
Referral and Consultation
Infection
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Shiels, M. T., Czaja, A. J., Taswell, H. F., Gerin, J. L., Purcell, R. H., Ludwig, J., ... Nelson, C. A. (1985). Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience. Gastroenterology, 89(6), 1230-1234.

Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience. / Shiels, Mark T.; Czaja, Albert J.; Taswell, Howard F.; Gerin, John L.; Purcell, Robert H.; Ludwig, Jurgen; Rakela, Jorge; Nelson, Cheryl A.

In: Gastroenterology, Vol. 89, No. 6, 1985, p. 1230-1234.

Research output: Contribution to journalArticle

Shiels, MT, Czaja, AJ, Taswell, HF, Gerin, JL, Purcell, RH, Ludwig, J, Rakela, J & Nelson, CA 1985, 'Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience', Gastroenterology, vol. 89, no. 6, pp. 1230-1234.
Shiels MT, Czaja AJ, Taswell HF, Gerin JL, Purcell RH, Ludwig J et al. Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience. Gastroenterology. 1985;89(6):1230-1234.
Shiels, Mark T. ; Czaja, Albert J. ; Taswell, Howard F. ; Gerin, John L. ; Purcell, Robert H. ; Ludwig, Jurgen ; Rakela, Jorge ; Nelson, Cheryl A. / Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience. In: Gastroenterology. 1985 ; Vol. 89, No. 6. pp. 1230-1234.
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