Fracture risk assessment: Improved evaluation of vertebral integrity among metastatic cancer patients to aid in surgical decision-making

Kurt E. Augustine, Jon J. Camp, David R. Holmes, Paul M. Huddleston, Lichun Lu, Michael J. Yaszemski, Richard A. Robb, Mayo Clinic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Failure of the spine's structural integrity from metastatic disease can lead to both pain and neurologic deficit. Fractures that require treatment occur in over 30% of bony metastases. Our objective is to use computed tomography (CT) in conjunction with analytic techniques that have been previously developed to predict fracture risk in cancer patients with metastatic disease to the spine. Current clinical practice for cancer patients with spine metastasis often requires an empirical decision regarding spinal reconstructive surgery. Early image-based software systems used for CT analysis are time consuming and poorly suited for clinical application. The Biomedical Image Resource (BIR) at Mayo Clinic, Rochester has developed an image analysis computer program that calculates from CT scans, the residual load-bearing capacity in a vertebra with metastatic cancer. The Spine Cancer Assessment (SCA) program is built on a platform designed for clinical practice, with a workflow format that allows for rapid selection of patient CT exams, followed by guided image analysis tasks, resulting in a fracture risk report. The analysis features allow the surgeon to quickly isolate a single vertebra and obtain an immediate pre-surgical multiple parallel section composite beam fracture risk analysis based on algorithms developed at Mayo Clinic. The analysis software is undergoing clinical validation studies. We expect this approach will facilitate patient management and utilization of reliable guidelines for selecting among various treatment option based on fracture risk.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - May 14 2012
EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 5 2012Feb 7 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8317
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/5/122/7/12

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Keywords

  • Fracture risk assessment
  • Spinal metastatic cancer
  • Vertebral strength analysis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Augustine, K. E., Camp, J. J., Holmes, D. R., Huddleston, P. M., Lu, L., Yaszemski, M. J., Robb, R. A., & Clinic, M. (2012). Fracture risk assessment: Improved evaluation of vertebral integrity among metastatic cancer patients to aid in surgical decision-making. In Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging [83171A] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8317). https://doi.org/10.1117/12.912870