Fornix stimulation induces metabolic activity and dopaminergic response in the nucleus accumbens

Hojin Shin, Sang Yoon Lee, Hyun U. Cho, Yoonbae Oh, In Young Kim, Kendall H. Lee, Dong Pyo Jang, Hoon Ki Min

Research output: Contribution to journalArticle

Abstract

The Papez circuit, including the fornix white matter bundle, is a well-known neural network that is involved in multiple limbic functions such as memory and emotional expression. We previously reported a large-animal study of deep brain stimulation (DBS) in the fornix that found stimulation-induced hemodynamic responses in both the medial limbic and corticolimbic circuits on functional resonance imaging (fMRI) and evoked dopamine responses in the nucleus accumbens (NAc), as measured by fast-scan cyclic voltammetry (FSCV). The effects of DBS on the fornix are challenging to analyze, given its structural complexity and connection to multiple neuronal networks. In this study, we extend our earlier work to a rodent model wherein we characterize regional brain activity changes resulting from fornix stimulation using fludeoxyglucose (18 F-FDG) micro positron emission tomography (PET) and monitor neurochemical changes using FSCV with pharmacological confirmation. Both global functional changes and local changes were measured in a rodent model of fornix DBS. Functional brain activity was measured by micro-PET, and the neurochemical changes in local areas were monitored by FSCV. Micro-PET images revealed increased glucose metabolism within the medial limbic and corticolimbic circuits. Neurotransmitter efflux induced by fornix DBS was monitored at NAc by FSCV and identified by specific neurotransmitter reuptake inhibitors. We found a significant increase in the metabolic activity in several key regions of the medial limbic circuits and dopamine efflux in the NAc following fornix stimulation. These results suggest that electrical stimulation of the fornix modulates the activity of brain memory circuits, including the hippocampus and NAc within the dopaminergic pathway.

Original languageEnglish (US)
Article number1109
JournalFrontiers in Neuroscience
Volume13
Issue numberOCT
DOIs
StatePublished - Jan 1 2019

Fingerprint

Deep Brain Stimulation
Nucleus Accumbens
Brain Fornix
Positron-Emission Tomography
Neurotransmitter Uptake Inhibitors
Rodentia
Dopamine
Brain
Fluorodeoxyglucose F18
Electric Stimulation
Neurotransmitter Agents
Hippocampus
Hemodynamics
Magnetic Resonance Imaging
Pharmacology
Glucose

Keywords

  • Deep brain stimulation
  • Dopamine
  • Fast-scan cyclic voltammetry
  • Fornix
  • Nucleus accumbens
  • Positron emission tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fornix stimulation induces metabolic activity and dopaminergic response in the nucleus accumbens. / Shin, Hojin; Lee, Sang Yoon; Cho, Hyun U.; Oh, Yoonbae; Kim, In Young; Lee, Kendall H.; Jang, Dong Pyo; Min, Hoon Ki.

In: Frontiers in Neuroscience, Vol. 13, No. OCT, 1109, 01.01.2019.

Research output: Contribution to journalArticle

Shin, Hojin ; Lee, Sang Yoon ; Cho, Hyun U. ; Oh, Yoonbae ; Kim, In Young ; Lee, Kendall H. ; Jang, Dong Pyo ; Min, Hoon Ki. / Fornix stimulation induces metabolic activity and dopaminergic response in the nucleus accumbens. In: Frontiers in Neuroscience. 2019 ; Vol. 13, No. OCT.
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