Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles

Roberto Buccione; James D. Orth; Mark A. McNiven

doi:10.1038/nrm1436

Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles

Roberto Buccione, James D. Orth, Mark A. McNiven

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

467 Scopus citations

Abstract

The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation - which is mediated by a highly conserved actin-membrane apparatus - these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.

Original language	English (US)
Pages (from-to)	647-657
Number of pages	11
Journal	Nature Reviews Molecular Cell Biology
Volume	5
Issue number	8
DOIs	https://doi.org/10.1038/nrm1436
State	Published - Aug 2004

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm1436

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title = "Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles",

abstract = "The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation - which is mediated by a highly conserved actin-membrane apparatus - these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.",

author = "Roberto Buccione and Orth, {James D.} and McNiven, {Mark A.}",

note = "Funding Information: Work in the R.B. laboratory is supported by the Italian Association for Cancer Research (AIRC, Milano, Italy). Work in the M.A.M. laboratory is supported by funding from the National Institutes of Health and Mayo Foundation. We thank A. Teti and M. Baldassarre for insightful discussions and K. Simmons for help and editorial advice during the preparation of this review.",

year = "2004",

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doi = "10.1038/nrm1436",

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T2 - Podosomes, invadopodia and circular dorsal ruffles

AU - Buccione, Roberto

AU - Orth, James D.

AU - McNiven, Mark A.

N1 - Funding Information: Work in the R.B. laboratory is supported by the Italian Association for Cancer Research (AIRC, Milano, Italy). Work in the M.A.M. laboratory is supported by funding from the National Institutes of Health and Mayo Foundation. We thank A. Teti and M. Baldassarre for insightful discussions and K. Simmons for help and editorial advice during the preparation of this review.

PY - 2004/8

Y1 - 2004/8

N2 - The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation - which is mediated by a highly conserved actin-membrane apparatus - these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.

AB - The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation - which is mediated by a highly conserved actin-membrane apparatus - these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.

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Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles

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