TY - JOUR
T1 - Follicular lymphoma transformation to dual translocated Burkitt-like lymphoma
T2 - Improved disease control associated with radiation therapy
AU - Parker, Stacey M.
AU - Olteanu, Horatiu
AU - Vantuinen, Peter
AU - Lawton, Colleen A.
AU - Schultz, Christopher J.
AU - Christians, Kathleen K.
AU - Fenske, Timothy S.
PY - 2009/12
Y1 - 2009/12
N2 - Dual translocated (or "dual hit") lymphomas are highly aggressive B cell neoplasms associated with an extremely poor prognosis. The optimal treatment for these lymphomas remains undefined. We present two cases of follicular lymphoma with transformation to Burkitt-like lymphoma. In both cases dual translocations involving both the bcl-2 and c-myc loci were present. Each patient underwent intensive induction immunochemotherapy followed by autologous stem cell transplantation and radiation therapy. The first patient received post-transplant mediastinal radiation and developed recurrence in multiple areas outside of the radiation field. The second patient received total body irradiation as part of the conditioning regimen, and is without recurrence 18 months after transplant, and 24 months after diagnosis of the dual translocated lymphoma. We review dual translocation B cell lymphoma in the setting of transformation from follicular lymphoma, and suggest a potential role for total body irradiation in the management of this highly aggressive non-Hodgkin lymphoma.
AB - Dual translocated (or "dual hit") lymphomas are highly aggressive B cell neoplasms associated with an extremely poor prognosis. The optimal treatment for these lymphomas remains undefined. We present two cases of follicular lymphoma with transformation to Burkitt-like lymphoma. In both cases dual translocations involving both the bcl-2 and c-myc loci were present. Each patient underwent intensive induction immunochemotherapy followed by autologous stem cell transplantation and radiation therapy. The first patient received post-transplant mediastinal radiation and developed recurrence in multiple areas outside of the radiation field. The second patient received total body irradiation as part of the conditioning regimen, and is without recurrence 18 months after transplant, and 24 months after diagnosis of the dual translocated lymphoma. We review dual translocation B cell lymphoma in the setting of transformation from follicular lymphoma, and suggest a potential role for total body irradiation in the management of this highly aggressive non-Hodgkin lymphoma.
KW - Autologous hematopoietic stem cell transplantation
KW - Burkitt-like lymphoma
KW - Double-hit lymphoma
KW - Dual translocated lymphoma
KW - Radiation therapy
KW - Transformed lymphoma
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U2 - 10.1007/s12185-009-0444-9
DO - 10.1007/s12185-009-0444-9
M3 - Article
C2 - 19937165
AN - SCOPUS:73449127535
SN - 0925-5710
VL - 90
SP - 616
EP - 622
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -