TY - JOUR
T1 - Fish-rich diet, leptin, and body mass
AU - Winnicki, Mikolaj
AU - Somers, Virend K.
AU - Accurso, Valentina
AU - Phillips, Bradley G.
AU - Puato, Massimo
AU - Palatini, Paolo
AU - Pauletto, Paolo
PY - 2002/7/16
Y1 - 2002/7/16
N2 - Background - Leptin has been implicated in cardiovascular disease. A diet rich in fish has been associated with decreased cardiac and vascular risk. Methods and Results - We examined the relationship between diet and leptin in 2 related homogeneous African tribal populations of Tanzania. One tribe consumes freshwater fish as their main diet component (n=279), and the other tribe consumes a primarily vegetarian diet (n=329). In multivariate analysis, plasma leptin levels were associated with type of diet (F=14.3, P<0.001), independent of age, body mass index, body fat, alcohol consumption, or insulin. Both male (2.5±2 [fish diet] versus 11.2±2.4 [vegetarian diet] ng/mL, P=0.017) and female (5.0±1.9 [fish diet] versus 11.8±1.4 [vegetarian diet] ng/mL, P=0.007) fish eaters had lower plasma leptin levels than did their vegetable diet counterparts, even though body mass index values were virtually identical. Conclusions - A diet rich in fish is associated with lower plasma leptin, independent of body fat. These findings may have implications for understanding the reduced cardiovascular risk in subjects on a high-fish diet.
AB - Background - Leptin has been implicated in cardiovascular disease. A diet rich in fish has been associated with decreased cardiac and vascular risk. Methods and Results - We examined the relationship between diet and leptin in 2 related homogeneous African tribal populations of Tanzania. One tribe consumes freshwater fish as their main diet component (n=279), and the other tribe consumes a primarily vegetarian diet (n=329). In multivariate analysis, plasma leptin levels were associated with type of diet (F=14.3, P<0.001), independent of age, body mass index, body fat, alcohol consumption, or insulin. Both male (2.5±2 [fish diet] versus 11.2±2.4 [vegetarian diet] ng/mL, P=0.017) and female (5.0±1.9 [fish diet] versus 11.8±1.4 [vegetarian diet] ng/mL, P=0.007) fish eaters had lower plasma leptin levels than did their vegetable diet counterparts, even though body mass index values were virtually identical. Conclusions - A diet rich in fish is associated with lower plasma leptin, independent of body fat. These findings may have implications for understanding the reduced cardiovascular risk in subjects on a high-fish diet.
KW - Diet
KW - Fatty acids
KW - Risk factors
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U2 - 10.1161/01.CIR.0000025241.01418.4D
DO - 10.1161/01.CIR.0000025241.01418.4D
M3 - Article
C2 - 12119240
AN - SCOPUS:0037118696
SN - 0009-7322
VL - 106
SP - 289
EP - 291
JO - Circulation
JF - Circulation
IS - 3
ER -