Filling the holes in cystic kidney disease research

Lisa M. Guay-Woodford, Elizabeth Henske, Peter Igarashi, Ronald D. Perrone, Berenice Reed-Gitomer, Stefan Somlo, Vicente E. Torres, Christian J. Ketchum, Robert A. Star, Michael F. Flessner, Rebekah S. Rasooly

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Kidney disease is a significant medical and public health problem. The National Institute of Diabetes and Digestive and Kidney Diseases recently asked the community to identify research objectives, which, if addressed, could improve understanding of basic kidney function and aid in prevention, treatment, and reversal of kidney disease. The Kidney Research National Dialogue invited interested parties to submit, discuss, and prioritize ideas using an interactive website; 1600 participants posted more than 300 ideas covering all areas of kidney disease, including the cystic kidney diseases. Although much is known about the genetics and pathogenesis of cystic diseases, there remain challenges to our understanding of the fundamentalmechanisms of cyst formation,what genes act as modifiers to cause variable responses in different people, and howto detect andmonitor disease progression. This article summarizes key research questions for cystic kidney diseases.

Original languageEnglish (US)
Pages (from-to)1799-1801
Number of pages3
JournalClinical Journal of the American Society of Nephrology
Volume9
Issue number10
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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    Guay-Woodford, L. M., Henske, E., Igarashi, P., Perrone, R. D., Reed-Gitomer, B., Somlo, S., Torres, V. E., Ketchum, C. J., Star, R. A., Flessner, M. F., & Rasooly, R. S. (2014). Filling the holes in cystic kidney disease research. Clinical Journal of the American Society of Nephrology, 9(10), 1799-1801. https://doi.org/10.2215/CJN.03410414