Fibrolamellar hepatocellular carcinoma: Exploring molecular mechanisms and differentiation pathways to better understand disease outcomes and prognosis

Cassandra A. Kersten, Elise N. Sloey, Eric Zhou, Ying Peng, Michael S. Torbenson, Yi Guo

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Fibrolamellar hepatocellular carcinoma (FLC) is a rare but aggressive liver cancer of children that occurs predominantly in teenagers without a history of liver disease. Surgical resection remains the only therapeutic option, and the recurrence rate is extremely high (>50% within 3 years). A newly discovered chromosomal deletion that occurs in the majority of FLCs generates a novel kinase fusion between DnaJ heat shock protein family member B1 (DNAJB1) and protein kinase cAMP-activated catalytic subunit alpha (PRKACA) (DNAJB1-PRKACA). Despite its high penetrance and apparent specificity for FLC, the oncogenic role of this fusion event remains unclear. In this review article, we discuss the histology, presentation and diagnosis, current treatment, and roles of the DNAJB1-PRKACA as well as research models contributing to our understanding of this disease.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalLiver Research
Volume1
Issue number4
DOIs
StatePublished - Dec 2017

Keywords

  • DnaJ heat shock protein family member B1 (DNAJB1)
  • Fibrolamellar hepatocellular carcinoma (FLC)
  • Liver cancer
  • Pediatric cancer
  • Protein kinase cAMP-activated catalytic subunit alpha (PRKACA)

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Fingerprint Dive into the research topics of 'Fibrolamellar hepatocellular carcinoma: Exploring molecular mechanisms and differentiation pathways to better understand disease outcomes and prognosis'. Together they form a unique fingerprint.

Cite this