Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda, Ernst Lengyel

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Curtis et al. show that metastasizing ovarian cancer cells can mobilize glycogen as an energy source, leading to increased proliferation, invasion, and metastasis, following their interaction with cancer-associated fibroblasts (CAFs). This process is dependent on p38α MAPK activation in CAFs and inhibition of the pathway reduced metastatic tumor growth in vivo.

Original languageEnglish (US)
Pages (from-to)141-155.e9
JournalCell Metabolism
Volume29
Issue number1
DOIs
StatePublished - Jan 8 2019

Keywords

  • PGM1
  • cancer-associated fibroblast
  • glycogen
  • glycogen phosphorylase
  • metabolism
  • metastasis
  • omentum
  • ovarian cancer
  • p38-MAPK
  • phosphoproteomics

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Curtis, M., Kenny, H. A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N., Gao, X., Yamada, S. D., Lastra, R., Montag, A., Ahsan, N., Locasale, J. W., Salomon, A. R., Nebreda, A. R., & Lengyel, E. (2019). Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metabolism, 29(1), 141-155.e9. https://doi.org/10.1016/j.cmet.2018.08.007