Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

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13 Citations (Scopus)

Abstract

Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalCurrent Opinion in Gastroenterology
Volume31
Issue number3
DOIs
StatePublished - May 27 2015

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Receptor, Fibroblast Growth Factor, Type 2
Cholangiocarcinoma
Fibroblast Growth Factors
Therapeutics

Keywords

  • cholangiocarcinoma
  • fibroblast growth factor receptor 2 signaling
  • fibroblast growth factor receptor 2 targeting

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma",
abstract = "Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.",
keywords = "cholangiocarcinoma, fibroblast growth factor receptor 2 signaling, fibroblast growth factor receptor 2 targeting",
author = "Borad, {Mitesh J} and Gores, {Gregory James} and Roberts, {Lewis Rowland}",
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AU - Borad, Mitesh J

AU - Gores, Gregory James

AU - Roberts, Lewis Rowland

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Y1 - 2015/5/27

N2 - Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

AB - Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

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