Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

Mitesh J. Borad; Gregory J. Gores; Lewis R. Roberts

doi:10.1097/MOG.0000000000000171

Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

Mitesh J. Borad, Gregory J. Gores, Lewis R. Roberts

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

Original language	English (US)
Pages (from-to)	264-268
Number of pages	5
Journal	Current Opinion in Gastroenterology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1097/MOG.0000000000000171
State	Published - May 27 2015

Keywords

cholangiocarcinoma
fibroblast growth factor receptor 2 signaling
fibroblast growth factor receptor 2 targeting

ASJC Scopus subject areas

Gastroenterology

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10.1097/MOG.0000000000000171

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title = "Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma",

abstract = "Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.",

keywords = "cholangiocarcinoma, fibroblast growth factor receptor 2 signaling, fibroblast growth factor receptor 2 targeting",

author = "Borad, {Mitesh J.} and Gores, {Gregory J.} and Roberts, {Lewis R.}",

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T1 - Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

AU - Borad, Mitesh J.

AU - Gores, Gregory J.

AU - Roberts, Lewis R.

PY - 2015/5/27

Y1 - 2015/5/27

N2 - Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

AB - Purpose of review This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent findings Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Summary Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

KW - cholangiocarcinoma

KW - fibroblast growth factor receptor 2 signaling

KW - fibroblast growth factor receptor 2 targeting

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Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

Abstract

Keywords

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