Fibroblast growth factor 23, parathyroid hormone, and 1α,25- dihydroxyvitamin D in surgically treated primary hyperparathyroidism

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Abstract

OBJECTIVE: To determine whether fibroblast growth factor 23 (FGF23) contributes to the hypophosphatemia of primary hyperparathyroidism. PATIENTS AND METHODS: Thirteen adult patients with primary hyperparathyroidism had serum collected before and after parathyroidectomy for analysis of inorganic phosphorus, calcium, 1α,25-dihydroxyvitamin D (1α,2B[OH] 2D), parathyroid hormone (PTH), FGF23, creatinine, and bone-specific alkaline phosphatase (BSAP). Patients were recruited between July 24, 2003, and February 11, 2004. RESULTS: Before surgery, patients had elevated serum calcium and PTH concentrations. Serum phosphorus concentrations were In the low-normal range. The FGF23 concentrations were not elevated in patients with primary hyperparathyroidism compared with healthy contrals. Within 24 hours of surgery, serum calcium, FFH, 1α,25(OH)2D, and BSAP concentrations were lower (P<.002 for all) and phosphorus concentrations were higher (P=.003) than in the preoperative state. The FGF23 concentrations were similar 1 day and 6 weeks after surgery. The FGF23 concentrations did not correlate with serum phosphorus, calcium, PTH, 1α,25(OH)2D, creatinine, or BSAP concentrations in the preoperative or postoperative state. CONCLUSION: Parathyroid hormone is the major regulator of serum phosphorus concentrations in patients with primary hyerparathyroidism. Fibroblast growth factor 23 does not appear to play a role in phosphorus homeostasis in patients with surgically treated primary hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)1508-1513
Number of pages6
JournalMayo Clinic Proceedings
Volume79
Issue number12
StatePublished - 2004

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Primary Hyperparathyroidism
Parathyroid Hormone
Phosphorus
Serum
Calcium
Alkaline Phosphatase
Bone and Bones
Creatinine
Hypophosphatemia
Parathyroidectomy
1,25-dihydroxyvitamin D
fibroblast growth factor 23
Reference Values
Homeostasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{194e58cf21874786bfbaae7a06c9506d,
title = "Fibroblast growth factor 23, parathyroid hormone, and 1α,25- dihydroxyvitamin D in surgically treated primary hyperparathyroidism",
abstract = "OBJECTIVE: To determine whether fibroblast growth factor 23 (FGF23) contributes to the hypophosphatemia of primary hyperparathyroidism. PATIENTS AND METHODS: Thirteen adult patients with primary hyperparathyroidism had serum collected before and after parathyroidectomy for analysis of inorganic phosphorus, calcium, 1α,25-dihydroxyvitamin D (1α,2B[OH] 2D), parathyroid hormone (PTH), FGF23, creatinine, and bone-specific alkaline phosphatase (BSAP). Patients were recruited between July 24, 2003, and February 11, 2004. RESULTS: Before surgery, patients had elevated serum calcium and PTH concentrations. Serum phosphorus concentrations were In the low-normal range. The FGF23 concentrations were not elevated in patients with primary hyperparathyroidism compared with healthy contrals. Within 24 hours of surgery, serum calcium, FFH, 1α,25(OH)2D, and BSAP concentrations were lower (P<.002 for all) and phosphorus concentrations were higher (P=.003) than in the preoperative state. The FGF23 concentrations were similar 1 day and 6 weeks after surgery. The FGF23 concentrations did not correlate with serum phosphorus, calcium, PTH, 1α,25(OH)2D, creatinine, or BSAP concentrations in the preoperative or postoperative state. CONCLUSION: Parathyroid hormone is the major regulator of serum phosphorus concentrations in patients with primary hyerparathyroidism. Fibroblast growth factor 23 does not appear to play a role in phosphorus homeostasis in patients with surgically treated primary hyperparathyroidism.",
author = "Peter Tebben and Singh, {Ravinder Jit} and Bart Clarke and Rajiv Kumar",
year = "2004",
language = "English (US)",
volume = "79",
pages = "1508--1513",
journal = "Mayo Clinic Proceedings",
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TY - JOUR

T1 - Fibroblast growth factor 23, parathyroid hormone, and 1α,25- dihydroxyvitamin D in surgically treated primary hyperparathyroidism

AU - Tebben, Peter

AU - Singh, Ravinder Jit

AU - Clarke, Bart

AU - Kumar, Rajiv

PY - 2004

Y1 - 2004

N2 - OBJECTIVE: To determine whether fibroblast growth factor 23 (FGF23) contributes to the hypophosphatemia of primary hyperparathyroidism. PATIENTS AND METHODS: Thirteen adult patients with primary hyperparathyroidism had serum collected before and after parathyroidectomy for analysis of inorganic phosphorus, calcium, 1α,25-dihydroxyvitamin D (1α,2B[OH] 2D), parathyroid hormone (PTH), FGF23, creatinine, and bone-specific alkaline phosphatase (BSAP). Patients were recruited between July 24, 2003, and February 11, 2004. RESULTS: Before surgery, patients had elevated serum calcium and PTH concentrations. Serum phosphorus concentrations were In the low-normal range. The FGF23 concentrations were not elevated in patients with primary hyperparathyroidism compared with healthy contrals. Within 24 hours of surgery, serum calcium, FFH, 1α,25(OH)2D, and BSAP concentrations were lower (P<.002 for all) and phosphorus concentrations were higher (P=.003) than in the preoperative state. The FGF23 concentrations were similar 1 day and 6 weeks after surgery. The FGF23 concentrations did not correlate with serum phosphorus, calcium, PTH, 1α,25(OH)2D, creatinine, or BSAP concentrations in the preoperative or postoperative state. CONCLUSION: Parathyroid hormone is the major regulator of serum phosphorus concentrations in patients with primary hyerparathyroidism. Fibroblast growth factor 23 does not appear to play a role in phosphorus homeostasis in patients with surgically treated primary hyperparathyroidism.

AB - OBJECTIVE: To determine whether fibroblast growth factor 23 (FGF23) contributes to the hypophosphatemia of primary hyperparathyroidism. PATIENTS AND METHODS: Thirteen adult patients with primary hyperparathyroidism had serum collected before and after parathyroidectomy for analysis of inorganic phosphorus, calcium, 1α,25-dihydroxyvitamin D (1α,2B[OH] 2D), parathyroid hormone (PTH), FGF23, creatinine, and bone-specific alkaline phosphatase (BSAP). Patients were recruited between July 24, 2003, and February 11, 2004. RESULTS: Before surgery, patients had elevated serum calcium and PTH concentrations. Serum phosphorus concentrations were In the low-normal range. The FGF23 concentrations were not elevated in patients with primary hyperparathyroidism compared with healthy contrals. Within 24 hours of surgery, serum calcium, FFH, 1α,25(OH)2D, and BSAP concentrations were lower (P<.002 for all) and phosphorus concentrations were higher (P=.003) than in the preoperative state. The FGF23 concentrations were similar 1 day and 6 weeks after surgery. The FGF23 concentrations did not correlate with serum phosphorus, calcium, PTH, 1α,25(OH)2D, creatinine, or BSAP concentrations in the preoperative or postoperative state. CONCLUSION: Parathyroid hormone is the major regulator of serum phosphorus concentrations in patients with primary hyerparathyroidism. Fibroblast growth factor 23 does not appear to play a role in phosphorus homeostasis in patients with surgically treated primary hyperparathyroidism.

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