Fetal lower urinary tract obstruction: What should we tell the prospective parents?

Eniola Raheem Ibirogba, Sina Haeri, Rodrigo Ruano

Research output: Contribution to journalReview articlepeer-review

Abstract

Fetal lower urinary tract obstruction (LUTO), which often results in marked perinatal morbidity and mortality, is caused by a heterogeneous group of anatomical defects that lead to blockage of the urethra. The classic prenatal presentation of LUTO includes megacystis with hydronephrosis. While mild forms of the disease can be associated with favorable outcomes, more severe disease commonly leads to dysplastic changes in the fetal kidneys, and ultimately oligohydramnios, which can result in secondary pulmonary hypoplasia and renal failure at birth. The aim of this review is to provide practitioners with a general overview of the diagnosis and treatment of LUTO based on disease severity, along with some points to consider when counseling prospective parents of fetuses with this condition.

Original languageEnglish (US)
Pages (from-to)661-668
Number of pages8
JournalPrenatal Diagnosis
Volume40
Issue number6
DOIs
StatePublished - May 1 2020

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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