TY - JOUR
T1 - Fetal lower urinary tract obstruction
T2 - What should we tell the prospective parents?
AU - Ibirogba, Eniola Raheem
AU - Haeri, Sina
AU - Ruano, Rodrigo
N1 - Publisher Copyright:
© 2020 John Wiley & Sons, Ltd.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Fetal lower urinary tract obstruction (LUTO), which often results in marked perinatal morbidity and mortality, is caused by a heterogeneous group of anatomical defects that lead to blockage of the urethra. The classic prenatal presentation of LUTO includes megacystis with hydronephrosis. While mild forms of the disease can be associated with favorable outcomes, more severe disease commonly leads to dysplastic changes in the fetal kidneys, and ultimately oligohydramnios, which can result in secondary pulmonary hypoplasia and renal failure at birth. The aim of this review is to provide practitioners with a general overview of the diagnosis and treatment of LUTO based on disease severity, along with some points to consider when counseling prospective parents of fetuses with this condition.
AB - Fetal lower urinary tract obstruction (LUTO), which often results in marked perinatal morbidity and mortality, is caused by a heterogeneous group of anatomical defects that lead to blockage of the urethra. The classic prenatal presentation of LUTO includes megacystis with hydronephrosis. While mild forms of the disease can be associated with favorable outcomes, more severe disease commonly leads to dysplastic changes in the fetal kidneys, and ultimately oligohydramnios, which can result in secondary pulmonary hypoplasia and renal failure at birth. The aim of this review is to provide practitioners with a general overview of the diagnosis and treatment of LUTO based on disease severity, along with some points to consider when counseling prospective parents of fetuses with this condition.
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U2 - 10.1002/pd.5669
DO - 10.1002/pd.5669
M3 - Review article
C2 - 32065667
AN - SCOPUS:85080064152
SN - 0197-3851
VL - 40
SP - 661
EP - 668
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 6
ER -