Abstract
Although a large number of studies have addressed the age-related changes in bone mineral density (BMD), there is a paucity of data for the assessment of femoral strength loss with age in both genders. We determined the variation of strength with age in femurs of women and men by mechanical tests on a cohort of 100 cadaveric femurs. In addition, the age-related neck BMD loss in our cadaveric cohort was found to be similar with BMD loss of four published population-based studies. Given the strong correlation found in our cadaveric study between BMD and femoral strength, we also estimated the femoral strength of the four populations based on their reported neck BMDs. Our study showed that men's femurs in our cadaveric cohort were stronger than women's femurs by about 800 N at the same BMD level, and by 1750 N at the same age. The strength differences were not explained satisfactorily by the size difference between men's and women's bones. Similar to the findings of clinical studies, the BMD values of men at all ages were larger than that of women. The age-related loss rates in BMD and strength were not statistically different between the two genders of our cadaveric cohort. After normalization, strength decreased more than 40% faster than BMD. On average, men reached a certain BMD value about 16 years later than women, and for strength about 23 years later, which may explain the higher rate of hip fracture in postmenopausal women. In patient population cohorts men reached a similar BMD value about 16 to 25 years later than women, whereas for estimated strength, sometimes more than 40 years later.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2200-2206 |
| Number of pages | 7 |
| Journal | Journal of Bone and Mineral Research |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2015 |
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Keywords
- AGE-RELATED BONE LOSS
- BONE MINERAL DENSITY
- CADAVERIC TESTS
- FEMORAL FRACTURE
- HIP FRACTURE
- OSTEOPOROSIS
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Orthopedics and Sports Medicine
Cite this
Femoral Strength Changes Faster with Age Than BMD in Both Women and Men : A Biomechanical Study. / Rezaei, Asghar; Dragomir Daescu, M. (Dan).
In: Journal of Bone and Mineral Research, Vol. 30, No. 12, 01.12.2015, p. 2200-2206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Femoral Strength Changes Faster with Age Than BMD in Both Women and Men
T2 - A Biomechanical Study
AU - Rezaei, Asghar
AU - Dragomir Daescu, M. (Dan)
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Although a large number of studies have addressed the age-related changes in bone mineral density (BMD), there is a paucity of data for the assessment of femoral strength loss with age in both genders. We determined the variation of strength with age in femurs of women and men by mechanical tests on a cohort of 100 cadaveric femurs. In addition, the age-related neck BMD loss in our cadaveric cohort was found to be similar with BMD loss of four published population-based studies. Given the strong correlation found in our cadaveric study between BMD and femoral strength, we also estimated the femoral strength of the four populations based on their reported neck BMDs. Our study showed that men's femurs in our cadaveric cohort were stronger than women's femurs by about 800 N at the same BMD level, and by 1750 N at the same age. The strength differences were not explained satisfactorily by the size difference between men's and women's bones. Similar to the findings of clinical studies, the BMD values of men at all ages were larger than that of women. The age-related loss rates in BMD and strength were not statistically different between the two genders of our cadaveric cohort. After normalization, strength decreased more than 40% faster than BMD. On average, men reached a certain BMD value about 16 years later than women, and for strength about 23 years later, which may explain the higher rate of hip fracture in postmenopausal women. In patient population cohorts men reached a similar BMD value about 16 to 25 years later than women, whereas for estimated strength, sometimes more than 40 years later.
AB - Although a large number of studies have addressed the age-related changes in bone mineral density (BMD), there is a paucity of data for the assessment of femoral strength loss with age in both genders. We determined the variation of strength with age in femurs of women and men by mechanical tests on a cohort of 100 cadaveric femurs. In addition, the age-related neck BMD loss in our cadaveric cohort was found to be similar with BMD loss of four published population-based studies. Given the strong correlation found in our cadaveric study between BMD and femoral strength, we also estimated the femoral strength of the four populations based on their reported neck BMDs. Our study showed that men's femurs in our cadaveric cohort were stronger than women's femurs by about 800 N at the same BMD level, and by 1750 N at the same age. The strength differences were not explained satisfactorily by the size difference between men's and women's bones. Similar to the findings of clinical studies, the BMD values of men at all ages were larger than that of women. The age-related loss rates in BMD and strength were not statistically different between the two genders of our cadaveric cohort. After normalization, strength decreased more than 40% faster than BMD. On average, men reached a certain BMD value about 16 years later than women, and for strength about 23 years later, which may explain the higher rate of hip fracture in postmenopausal women. In patient population cohorts men reached a similar BMD value about 16 to 25 years later than women, whereas for estimated strength, sometimes more than 40 years later.
KW - AGE-RELATED BONE LOSS
KW - BONE MINERAL DENSITY
KW - CADAVERIC TESTS
KW - FEMORAL FRACTURE
KW - HIP FRACTURE
KW - OSTEOPOROSIS
UR - http://www.scopus.com/inward/record.url?scp=84954056850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954056850&partnerID=8YFLogxK
U2 - 10.1002/jbmr.2572
DO - 10.1002/jbmr.2572
M3 - Article
C2 - 26096829
AN - SCOPUS:84954056850
VL - 30
SP - 2200
EP - 2206
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 12
ER -