Felbamate relieved trigeminal neuralgia

W. P. Cheshire

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: The analgesic efficacy of the novel anticonvulsant felbamate was evaluated in trigeminal neuralgia. Patients and Setting: This trial was offered in a tertiary referral center to three outpatients with severe pain who had exhausted other medical options, yet did not wish to undergo surgery. Interventions: Felbamate was prescribed as the sole analgesic for approximately 1 month. Outcome Measures: A visual analogue scale was utilized. Results: Felbamate potently diminished the severe pain of trigeminal neuralgia and was well tolerated. The drug was withdrawn because of subsequent reports elsewhere of aplastic anemia and hepatic failure associated with it when used for epilepsy. Conclusions: Preliminary evidence suggested that felbamate was effective in relieving trigeminal neuralgia. Stabilization of neuronal membrane depolarization was the most likely mechanism of action. However, significant potential risks preclude further use of felbamate in the management of nonmalignant pain. Principles that have proven useful in screening for new anticonvulsant drugs might be relevant to the development of methods by which to search for new analgesic drugs.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalClinical Journal of Pain
Volume11
Issue number2
StatePublished - 1995

Fingerprint

felbamate
Trigeminal Neuralgia
Analgesics
Anticonvulsants
Pain
Aplastic Anemia
Liver Failure
Pain Management
Visual Analog Scale
Tertiary Care Centers
Epilepsy
Outpatients
Outcome Assessment (Health Care)
Membranes

Keywords

  • Analgesic drug development
  • Antiepileptic drugs
  • Felbamate
  • Neuropathic pain
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Cheshire, W. P. (1995). Felbamate relieved trigeminal neuralgia. Clinical Journal of Pain, 11(2), 139-142.

Felbamate relieved trigeminal neuralgia. / Cheshire, W. P.

In: Clinical Journal of Pain, Vol. 11, No. 2, 1995, p. 139-142.

Research output: Contribution to journalArticle

Cheshire, WP 1995, 'Felbamate relieved trigeminal neuralgia', Clinical Journal of Pain, vol. 11, no. 2, pp. 139-142.
Cheshire, W. P. / Felbamate relieved trigeminal neuralgia. In: Clinical Journal of Pain. 1995 ; Vol. 11, No. 2. pp. 139-142.
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