Felbamate relieved trigeminal neuralgia

W. P. Cheshire

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objective: The analgesic efficacy of the novel anticonvulsant felbamate was evaluated in trigeminal neuralgia. Patients and Setting: This trial was offered in a tertiary referral center to three outpatients with severe pain who had exhausted other medical options, yet did not wish to undergo surgery. Interventions: Felbamate was prescribed as the sole analgesic for approximately 1 month. Outcome Measures: A visual analogue scale was utilized. Results: Felbamate potently diminished the severe pain of trigeminal neuralgia and was well tolerated. The drug was withdrawn because of subsequent reports elsewhere of aplastic anemia and hepatic failure associated with it when used for epilepsy. Conclusions: Preliminary evidence suggested that felbamate was effective in relieving trigeminal neuralgia. Stabilization of neuronal membrane depolarization was the most likely mechanism of action. However, significant potential risks preclude further use of felbamate in the management of nonmalignant pain. Principles that have proven useful in screening for new anticonvulsant drugs might be relevant to the development of methods by which to search for new analgesic drugs.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalClinical Journal of Pain
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1995

Keywords

  • Analgesic drug development
  • Antiepileptic drugs
  • Felbamate
  • Neuropathic pain
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Felbamate relieved trigeminal neuralgia'. Together they form a unique fingerprint.

  • Cite this