FEL experiments to study the effect pulse duration on the biological consequences of laser-induced stress waves

Thomas J Flotte, Apostolos G. Doukas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The therapeutic applications of laser-induced stress waves have been limited to the disruption of noncellular material such as renal stones, atheromatous plaque, vitreous strands and other ocular membranes. Recent experiments at the Wellman Laboratories of Photomedicine have demonstrated that there is also potential therapeutic applications of laser-induced stress waves for cellular processes. It has been established that stress waves can lead to selective killing of the cell cultures. The present studies are designed to investigate in a coherent way the parameters of the stress waves that can most efficiently cause cell death. This work coupled with the characterization of laser-induced pressure waves determine whether the scheme of selective killing of cells meditated by stress waves is a valid concept as a treatment. Laser-induced stress wave generation has unique properties when compared to other methods of generating pressure transients, particularly, ultrasound. These properties allow for the isolation of stress waves some of the other physical phenomena that occur during ultrasound and which frequently overwhelm the more subtle and potentially useful effects of the pressure transients. In combination with drugs, the laser-induced stress waves may offer a unique treatment regimen.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsH.A. Schwettman
Place of PublicationBellingham, WA, United States
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages169-174
Number of pages6
Volume1854
ISBN (Print)0819410802
StatePublished - 1993
Externally publishedYes
EventFree-Electron Laser Spectroscopy in Biology, Medicine, and Materials Science - Los Angeles, CA, USA
Duration: Jan 17 1993Jan 22 1993

Other

OtherFree-Electron Laser Spectroscopy in Biology, Medicine, and Materials Science
CityLos Angeles, CA, USA
Period1/17/931/22/93

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Flotte, T. J., & Doukas, A. G. (1993). FEL experiments to study the effect pulse duration on the biological consequences of laser-induced stress waves. In H. A. Schwettman (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1854, pp. 169-174). Publ by Society of Photo-Optical Instrumentation Engineers.