Feeding augments canine jejunal absorption via a hormonal mechanism

M. G. Sarr, K. A. Kelly, S. F. Phillips

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The aim of this study was to determine whether hormones mediate the postprandial increase in absorption of water, glucose, and electrolytes that occurs in the canine jejunum. In four dogs, a 75-cm isolated loop of jejunum was extrinsically denervated by autotransplantation. After recovery, the loop was perfused at 2.8 ml/min with an isotonic solution of 130 mM glucose, 80 mM NaCl, and trace amounts of [14C]PEG. Mean transit times through the loop were assessed concurrently with 0.5-ml boluses of [3H]PEG. Experiments were performed during fasting and after an oral meal of 200 g liver. Under steady-state conditions, net adsorption of water, glucose, sodium, and chloride was greater after feeding than during fasting. In contrast, mean transit times were nearly identical during fasting and after feeding. We concluded that the augmentation of jejunal absorption of water, glucose, and the electrolytes after feeding was brought about by mechanisms other than alterations in transit time or effects induced via the extrinsic nerves. The augmentation appeared to be mediated, in part by hormones.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalDigestive Diseases and Sciences
Volume26
Issue number11
StatePublished - 1981

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Canidae
Glucose
Fasting
Jejunum
Electrolytes
Water
Hormones
Isotonic Solutions
Autologous Transplantation
Sodium Chloride
Adsorption
Meals
Dogs
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sarr, M. G., Kelly, K. A., & Phillips, S. F. (1981). Feeding augments canine jejunal absorption via a hormonal mechanism. Digestive Diseases and Sciences, 26(11), 961-965.

Feeding augments canine jejunal absorption via a hormonal mechanism. / Sarr, M. G.; Kelly, K. A.; Phillips, S. F.

In: Digestive Diseases and Sciences, Vol. 26, No. 11, 1981, p. 961-965.

Research output: Contribution to journalArticle

Sarr, MG, Kelly, KA & Phillips, SF 1981, 'Feeding augments canine jejunal absorption via a hormonal mechanism', Digestive Diseases and Sciences, vol. 26, no. 11, pp. 961-965.
Sarr, M. G. ; Kelly, K. A. ; Phillips, S. F. / Feeding augments canine jejunal absorption via a hormonal mechanism. In: Digestive Diseases and Sciences. 1981 ; Vol. 26, No. 11. pp. 961-965.
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