Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (Results of the LOWTEMP pilot study)

David E. Kandzari; Alan Chu; Bruce R. Brodie; Thomas A. Stuckey; James B. Hermiller; George W. Vetrovec; Karen L. Hannan; Mitchell W. Krucoff; Robert H. Christenson; Raymond J. Gibbons; Kristina N. Sigmon; Jyostna Garg; Victor Hasselblad; Kenneth Collins; Robert A. Harrington; Peter B. Berger; Nicholas A. Chronos; Judith S. Hochman; Robert M. Califf

doi:10.1016/j.amjcard.2003.11.038

Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (Results of the LOWTEMP pilot study)

David E. Kandzari, Alan Chu, Bruce R. Brodie, Thomas A. Stuckey, James B. Hermiller, George W. Vetrovec, Karen L. Hannan, Mitchell W. Krucoff, Robert H. Christenson, Raymond J. Gibbons, Kristina N. Sigmon, Jyostna Garg, Victor Hasselblad, Kenneth Collins, Robert A. Harrington, Peter B. Berger, Nicholas A. Chronos, Judith S. Hochman, Robert M. Califf

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve creatinine kinase-MB and technetium-99m single-photon emission computed tomography sestamibi) and the quality of myocardial perfusion (continuous ST-segment monitoring). Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5°C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.

Original language	English (US)
Pages (from-to)	636-639
Number of pages	4
Journal	American Journal of Cardiology
Volume	93
Issue number	5
DOIs	https://doi.org/10.1016/j.amjcard.2003.11.038
State	Published - Mar 1 2004

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Kandzari, D. E., Chu, A., Brodie, B. R., Stuckey, T. A., Hermiller, J. B., Vetrovec, G. W., Hannan, K. L., Krucoff, M. W., Christenson, R. H., Gibbons, R. J., Sigmon, K. N., Garg, J., Hasselblad, V., Collins, K., Harrington, R. A., Berger, P. B., Chronos, N. A., Hochman, J. S., & Califf, R. M. (2004). Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (Results of the LOWTEMP pilot study). American Journal of Cardiology, 93(5), 636-639. https://doi.org/10.1016/j.amjcard.2003.11.038

Kandzari, DE, Chu, A, Brodie, BR, Stuckey, TA, Hermiller, JB, Vetrovec, GW, Hannan, KL, Krucoff, MW, Christenson, RH, Gibbons, RJ, Sigmon, KN, Garg, J, Hasselblad, V, Collins, K, Harrington, RA, Berger, PB, Chronos, NA, Hochman, JS & Califf, RM 2004, 'Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (Results of the LOWTEMP pilot study)', American Journal of Cardiology, vol. 93, no. 5, pp. 636-639. https://doi.org/10.1016/j.amjcard.2003.11.038

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title = "Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (Results of the LOWTEMP pilot study)",

abstract = "In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve creatinine kinase-MB and technetium-99m single-photon emission computed tomography sestamibi) and the quality of myocardial perfusion (continuous ST-segment monitoring). Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5°C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.",

author = "Kandzari, {David E.} and Alan Chu and Brodie, {Bruce R.} and Stuckey, {Thomas A.} and Hermiller, {James B.} and Vetrovec, {George W.} and Hannan, {Karen L.} and Krucoff, {Mitchell W.} and Christenson, {Robert H.} and Gibbons, {Raymond J.} and Sigmon, {Kristina N.} and Jyostna Garg and Victor Hasselblad and Kenneth Collins and Harrington, {Robert A.} and Berger, {Peter B.} and Chronos, {Nicholas A.} and Hochman, {Judith S.} and Califf, {Robert M.}",

note = "Funding Information: This work was supported by Alsius Corporation, Irvine, California. ",

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doi = "10.1016/j.amjcard.2003.11.038",

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AU - Kandzari, David E.

AU - Chu, Alan

AU - Brodie, Bruce R.

AU - Stuckey, Thomas A.

AU - Hermiller, James B.

AU - Vetrovec, George W.

AU - Hannan, Karen L.

AU - Krucoff, Mitchell W.

AU - Christenson, Robert H.

AU - Gibbons, Raymond J.

AU - Sigmon, Kristina N.

AU - Garg, Jyostna

AU - Hasselblad, Victor

AU - Collins, Kenneth

AU - Harrington, Robert A.

AU - Berger, Peter B.

AU - Chronos, Nicholas A.

AU - Hochman, Judith S.

AU - Califf, Robert M.

N1 - Funding Information: This work was supported by Alsius Corporation, Irvine, California.

PY - 2004/3/1

Y1 - 2004/3/1

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Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (Results of the LOWTEMP pilot study)

Abstract

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