Familial parkinsonism: Our experience and review

Melody A. Denson, Zbigniew K Wszolek

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

There is substantial interest in the possible role of genetic factors in the etiology of idiopathic parkinsonism (IP) and parkinsonism-plus syndromes (PPS). We have longitudinally investigated eight large kindreds from North America. Five families demonstrated IP features, two families represented PPS and in one family, neither a diagnosis of IP or PPS could be established. A literature review supported our findings; only half of the published kindreds presented with a clinical picture typical of IP. Genetic DNA analysis is in progress on our kindreds and on many families in our literature review. The results may clarify the etiology and classification of IP and PPS.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalParkinsonism and Related Disorders
Volume1
Issue number1
StatePublished - Jul 1995
Externally publishedYes

Fingerprint

Parkinsonian Disorders
North America
DNA

Keywords

  • Familial parkinsonism Idiopathic Parkinson's disease Parkinsonism-plus syndromes Genealogic and genetic investigations

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Geriatrics and Gerontology

Cite this

Familial parkinsonism : Our experience and review. / Denson, Melody A.; Wszolek, Zbigniew K.

In: Parkinsonism and Related Disorders, Vol. 1, No. 1, 07.1995, p. 35-46.

Research output: Contribution to journalArticle

@article{acfed141cfa940cf915a7d30109ef768,
title = "Familial parkinsonism: Our experience and review",
abstract = "There is substantial interest in the possible role of genetic factors in the etiology of idiopathic parkinsonism (IP) and parkinsonism-plus syndromes (PPS). We have longitudinally investigated eight large kindreds from North America. Five families demonstrated IP features, two families represented PPS and in one family, neither a diagnosis of IP or PPS could be established. A literature review supported our findings; only half of the published kindreds presented with a clinical picture typical of IP. Genetic DNA analysis is in progress on our kindreds and on many families in our literature review. The results may clarify the etiology and classification of IP and PPS.",
keywords = "Familial parkinsonism Idiopathic Parkinson's disease Parkinsonism-plus syndromes Genealogic and genetic investigations",
author = "Denson, {Melody A.} and Wszolek, {Zbigniew K}",
year = "1995",
month = "7",
language = "English (US)",
volume = "1",
pages = "35--46",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Familial parkinsonism

T2 - Our experience and review

AU - Denson, Melody A.

AU - Wszolek, Zbigniew K

PY - 1995/7

Y1 - 1995/7

N2 - There is substantial interest in the possible role of genetic factors in the etiology of idiopathic parkinsonism (IP) and parkinsonism-plus syndromes (PPS). We have longitudinally investigated eight large kindreds from North America. Five families demonstrated IP features, two families represented PPS and in one family, neither a diagnosis of IP or PPS could be established. A literature review supported our findings; only half of the published kindreds presented with a clinical picture typical of IP. Genetic DNA analysis is in progress on our kindreds and on many families in our literature review. The results may clarify the etiology and classification of IP and PPS.

AB - There is substantial interest in the possible role of genetic factors in the etiology of idiopathic parkinsonism (IP) and parkinsonism-plus syndromes (PPS). We have longitudinally investigated eight large kindreds from North America. Five families demonstrated IP features, two families represented PPS and in one family, neither a diagnosis of IP or PPS could be established. A literature review supported our findings; only half of the published kindreds presented with a clinical picture typical of IP. Genetic DNA analysis is in progress on our kindreds and on many families in our literature review. The results may clarify the etiology and classification of IP and PPS.

KW - Familial parkinsonism Idiopathic Parkinson's disease Parkinsonism-plus syndromes Genealogic and genetic investigations

UR - http://www.scopus.com/inward/record.url?scp=0002850656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002850656&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0002850656

VL - 1

SP - 35

EP - 46

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 1

ER -