Familial dilated cardiomyopathy

M. A. Schmidt, V. V. Michels, W. D. Edwards, Fletcher A Jr. Miller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Idiopathic dilated cardiomyopathy is generally considered a sporadic, nongenetic disorder, and reports of familial cases are often regarded as rare occurrences. Results of the present investigation of 6 families with this disorder suggest that familial forms of dilated cardiomyopathy occur more frequently than previously suspected. The familial nature of the dilated cardiomyopathy was not readily apparent in 3 of these families until thorough family investigations had been performed. The clinical symptoms and age of onset were variable from one family to another and within families. Based on these observations, it is recommended that all persons diagnosed with dilated cardiomyopathy have a thorough review of their family history. If there are any cases of unexplained heart disease, sudden unexpected death or syncopal episodes, further investigations of relatives should be performed. Echocardiography is a convenient noninvasive tool for investigating relatives. Early diagnosis of affected relatives is important for 2 reasons - treatment of significant arrhythmias may prevent sudden unexpected death, and genetic counseling can be provided.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalAmerican Journal of Medical Genetics
Volume31
Issue number1
StatePublished - 1988

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Dilated Cardiomyopathy
Sudden Death
Genetic Counseling
Syncope
Age of Onset
Echocardiography
Cardiac Arrhythmias
Early Diagnosis
Heart Diseases
Familial dilated cardiomyopathy

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Schmidt, M. A., Michels, V. V., Edwards, W. D., & Miller, F. A. J. (1988). Familial dilated cardiomyopathy. American Journal of Medical Genetics, 31(1), 135-143.

Familial dilated cardiomyopathy. / Schmidt, M. A.; Michels, V. V.; Edwards, W. D.; Miller, Fletcher A Jr.

In: American Journal of Medical Genetics, Vol. 31, No. 1, 1988, p. 135-143.

Research output: Contribution to journalArticle

Schmidt, MA, Michels, VV, Edwards, WD & Miller, FAJ 1988, 'Familial dilated cardiomyopathy', American Journal of Medical Genetics, vol. 31, no. 1, pp. 135-143.
Schmidt MA, Michels VV, Edwards WD, Miller FAJ. Familial dilated cardiomyopathy. American Journal of Medical Genetics. 1988;31(1):135-143.
Schmidt, M. A. ; Michels, V. V. ; Edwards, W. D. ; Miller, Fletcher A Jr. / Familial dilated cardiomyopathy. In: American Journal of Medical Genetics. 1988 ; Vol. 31, No. 1. pp. 135-143.
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