Familial adenomatous polyposis

William Rengifo-Cam, Kory W. Jasperson, Randall W. Burt, Niloy Jewel Samadder

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a prevalence of about one in 10,000 live births. It is classically characterized by the development of hundreds to thousands of adenomas in the colon and rectum that progress to colorectal cancer (CRC) in almost all individuals if left untreated. It typically presents in early adolescence and without any intervention, 95 % of patients will develop CRC by age 50. Adequate colonoscopy surveillance and prophylactic colectomy have reduced the incidence of CRC cases in FAP. This article examines the epidemiology, clinical presentation, genetic basis, differential diagnosis, endoscopic and surgical management of FAP.

Original languageEnglish (US)
Title of host publicationIntestinal Polyposis Syndromes
Subtitle of host publicationDiagnosis and Management
PublisherSpringer International Publishing
Number of pages23
ISBN (Electronic)9783319281032
ISBN (Print)9783319281018
StatePublished - Jan 1 2016
Externally publishedYes


  • AFAP
  • APC mutation
  • FAP
  • Hereditary colon cancer
  • Polyposis

ASJC Scopus subject areas

  • Medicine(all)


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