Familial adenomatous polyposis

William Rengifo-Cam; Kory W. Jasperson; Randall W. Burt; Niloy Jewel Samadder

doi:10.1007/978-3-319-28103-2_11

Familial adenomatous polyposis

William Rengifo-Cam, Kory W. Jasperson, Randall W. Burt, Niloy Jewel Samadder

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a prevalence of about one in 10,000 live births. It is classically characterized by the development of hundreds to thousands of adenomas in the colon and rectum that progress to colorectal cancer (CRC) in almost all individuals if left untreated. It typically presents in early adolescence and without any intervention, 95 % of patients will develop CRC by age 50. Adequate colonoscopy surveillance and prophylactic colectomy have reduced the incidence of CRC cases in FAP. This article examines the epidemiology, clinical presentation, genetic basis, differential diagnosis, endoscopic and surgical management of FAP.

Original language	English (US)
Title of host publication	Intestinal Polyposis Syndromes
Subtitle of host publication	Diagnosis and Management
Publisher	Springer International Publishing
Pages	173-195
Number of pages	23
ISBN (Electronic)	9783319281032
ISBN (Print)	9783319281018
DOIs	https://doi.org/10.1007/978-3-319-28103-2_11
State	Published - Jan 1 2016
Externally published	Yes

Keywords

AFAP
APC mutation
FAP
Hereditary colon cancer
Polyposis

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-319-28103-2_11

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title = "Familial adenomatous polyposis",

abstract = "Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a prevalence of about one in 10,000 live births. It is classically characterized by the development of hundreds to thousands of adenomas in the colon and rectum that progress to colorectal cancer (CRC) in almost all individuals if left untreated. It typically presents in early adolescence and without any intervention, 95 % of patients will develop CRC by age 50. Adequate colonoscopy surveillance and prophylactic colectomy have reduced the incidence of CRC cases in FAP. This article examines the epidemiology, clinical presentation, genetic basis, differential diagnosis, endoscopic and surgical management of FAP.",

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AU - Rengifo-Cam, William

AU - Jasperson, Kory W.

AU - Burt, Randall W.

AU - Samadder, Niloy Jewel

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Y1 - 2016/1/1

N2 - Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a prevalence of about one in 10,000 live births. It is classically characterized by the development of hundreds to thousands of adenomas in the colon and rectum that progress to colorectal cancer (CRC) in almost all individuals if left untreated. It typically presents in early adolescence and without any intervention, 95 % of patients will develop CRC by age 50. Adequate colonoscopy surveillance and prophylactic colectomy have reduced the incidence of CRC cases in FAP. This article examines the epidemiology, clinical presentation, genetic basis, differential diagnosis, endoscopic and surgical management of FAP.

AB - Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a prevalence of about one in 10,000 live births. It is classically characterized by the development of hundreds to thousands of adenomas in the colon and rectum that progress to colorectal cancer (CRC) in almost all individuals if left untreated. It typically presents in early adolescence and without any intervention, 95 % of patients will develop CRC by age 50. Adequate colonoscopy surveillance and prophylactic colectomy have reduced the incidence of CRC cases in FAP. This article examines the epidemiology, clinical presentation, genetic basis, differential diagnosis, endoscopic and surgical management of FAP.

KW - AFAP

KW - APC mutation

KW - FAP

KW - Hereditary colon cancer

KW - Polyposis

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BT - Intestinal Polyposis Syndromes

PB - Springer International Publishing

ER -

Familial adenomatous polyposis

Abstract

Keywords

ASJC Scopus subject areas

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