Factors Associated With Survival Following Radium-223 Treatment for Metastatic Castration-resistant Prostate Cancer

William W. Wong, Eric M. Anderson, Homan Mohammadi, Thomas B. Daniels, Steve E. Schild, Sameer R. Keole, C. Richard Choo, Katherine S. Tzou, Alan H Bryce, Thai H Ho, Fernando J. Quevedo, Sujay A. Vora

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Background: Radium-223 (223Ra) improves survival in patients with metastatic castration-resistant prostate cancer (mCRPC). This retrospective analysis was performed to better understand its efficacy in routine clinical practice and identify factors associated with survival. Materials and Methods: Sixty-four patients with mCRPC who received 223Ra between 2013 and 2015 were the basis of this retrospective study. Clinical outcomes and patient characteristics were obtained. Potential prognostic factors for survival were evaluated by univariate analysis using the log-rank test and multivariate analysis using the Cox proportional hazard method. Results: The median survival was 12.9 months. Twenty-one patients (33%) developed a skeletal event, and the median time to the first skeletal event was 4.4 months. In univariate analysis, factors significantly associated with survival included: no prior chemotherapy, ≤ 5 bone metastases, baseline prostate-specific antigen (PSA) ≤ 36 ng/mL, baseline alkaline phosphatase (ALP) < 115 U/L, baseline hemoglobin > 12 g/dL, ALP response after 223Ra treatment, PSA decrease during 223Ra treatment, and absence of > 25% PSA increase during 223Ra treatment. In multivariate analysis, 4 factors remained significant: no prior chemotherapy, ≤ 5 bone metastases, baseline ALP < 115 U/L, and ALP response after 223Ra treatment. Conclusion: When 223Ra is administered in routine clinical practice, clinical outcomes can be more variable than those reported in the randomized study owing to patient heterogeneity. Four factors were identified to be significantly associated with survival after 223Ra treatment. These pretreatment factors may be used as stratification factors in future studies to investigate whether 223Ra would be more effective for patients with newly diagnosed metastatic disease that is sensitive to androgen deprivation therapy.

Original languageEnglish (US)
JournalClinical Genitourinary Cancer
DOIs
StateAccepted/In press - Feb 27 2017

Keywords

  • Alpha-emitter
  • Bone metastasis
  • Bone-targeting agent
  • Palliative radiation
  • Radiopharmaceutical

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Wong, W. W., Anderson, E. M., Mohammadi, H., Daniels, T. B., Schild, S. E., Keole, S. R., Choo, C. R., Tzou, K. S., Bryce, A. H., Ho, T. H., Quevedo, F. J., & Vora, S. A. (Accepted/In press). Factors Associated With Survival Following Radium-223 Treatment for Metastatic Castration-resistant Prostate Cancer. Clinical Genitourinary Cancer. https://doi.org/10.1016/j.clgc.2017.04.016