Facial venous malformations are associated with cerebral developmental venous anomalies

Waleed Brinjikji, C. A. Hilditch, A. C. Tsang, P. J. Nicholson, T. Krings, R. Agid

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: A number of studies have demonstrated the existence of segmental vascular disorders affecting soft tissues of the head and neck along with the intracranial vasculature. The purpose of this study was to determine whether there is an association between cerebral developmental venous anomalies and venous malformations of the face, head, and neck. MATERIALS AND METHODS: A consecutive series of patients with head and neck venous malformations who underwent MR imaging of the brain with postcontrast T1- or T2-weighted imaging were included. Developmental venous anomaly prevalence in this patient population was compared with an age- and sex-matched control group without venous malformations at a ratio of 1:2. All images were interpreted by 2 neuroradiologists. Data were collected on venous malformation location, developmental venous anomaly location, developmental venous anomaly drainage pattern, and metameric location of venous malformations and developmental venous anomalies. Categoric variables were compared using χ2 tests. RESULTS: Forty-two patients with venous malformations were included. The mean age was 38.1 ± 11.1 years, and 78.6% of patients were female. The prevalence of developmental venous anomalies in this patient population was 28.6%. The control population of 84 patients had a mean age of 40.0±5.9 years, and 78.6% of patients were female. The prevalence of developmental venous anomalies in this patient population was 9.5% (P=.01). In 83.3% of cases, developmental venous anomalies were ipsilateral to the venous malformation, and in 75% of cases, they involved the same metamere. CONCLUSIONS: Our case-control study demonstrated a significant association between brain developmental venous anomalies and superficial venous malformations. These findings suggest that there may be a similar pathophysiologic origin for these 2 entities.

Original languageEnglish (US)
Pages (from-to)2103-2107
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume39
Issue number11
DOIs
StatePublished - Nov 1 2018

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Neck
Head
Population
Neuroimaging
Blood Vessels
Case-Control Studies
Drainage
Research Design
Control Groups
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Facial venous malformations are associated with cerebral developmental venous anomalies. / Brinjikji, Waleed; Hilditch, C. A.; Tsang, A. C.; Nicholson, P. J.; Krings, T.; Agid, R.

In: American Journal of Neuroradiology, Vol. 39, No. 11, 01.11.2018, p. 2103-2107.

Research output: Contribution to journalArticle

Brinjikji, Waleed ; Hilditch, C. A. ; Tsang, A. C. ; Nicholson, P. J. ; Krings, T. ; Agid, R. / Facial venous malformations are associated with cerebral developmental venous anomalies. In: American Journal of Neuroradiology. 2018 ; Vol. 39, No. 11. pp. 2103-2107.
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abstract = "BACKGROUND AND PURPOSE: A number of studies have demonstrated the existence of segmental vascular disorders affecting soft tissues of the head and neck along with the intracranial vasculature. The purpose of this study was to determine whether there is an association between cerebral developmental venous anomalies and venous malformations of the face, head, and neck. MATERIALS AND METHODS: A consecutive series of patients with head and neck venous malformations who underwent MR imaging of the brain with postcontrast T1- or T2∗-weighted imaging were included. Developmental venous anomaly prevalence in this patient population was compared with an age- and sex-matched control group without venous malformations at a ratio of 1:2. All images were interpreted by 2 neuroradiologists. Data were collected on venous malformation location, developmental venous anomaly location, developmental venous anomaly drainage pattern, and metameric location of venous malformations and developmental venous anomalies. Categoric variables were compared using χ2 tests. RESULTS: Forty-two patients with venous malformations were included. The mean age was 38.1 ± 11.1 years, and 78.6{\%} of patients were female. The prevalence of developmental venous anomalies in this patient population was 28.6{\%}. The control population of 84 patients had a mean age of 40.0±5.9 years, and 78.6{\%} of patients were female. The prevalence of developmental venous anomalies in this patient population was 9.5{\%} (P=.01). In 83.3{\%} of cases, developmental venous anomalies were ipsilateral to the venous malformation, and in 75{\%} of cases, they involved the same metamere. CONCLUSIONS: Our case-control study demonstrated a significant association between brain developmental venous anomalies and superficial venous malformations. These findings suggest that there may be a similar pathophysiologic origin for these 2 entities.",
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AU - Krings, T.

AU - Agid, R.

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N2 - BACKGROUND AND PURPOSE: A number of studies have demonstrated the existence of segmental vascular disorders affecting soft tissues of the head and neck along with the intracranial vasculature. The purpose of this study was to determine whether there is an association between cerebral developmental venous anomalies and venous malformations of the face, head, and neck. MATERIALS AND METHODS: A consecutive series of patients with head and neck venous malformations who underwent MR imaging of the brain with postcontrast T1- or T2∗-weighted imaging were included. Developmental venous anomaly prevalence in this patient population was compared with an age- and sex-matched control group without venous malformations at a ratio of 1:2. All images were interpreted by 2 neuroradiologists. Data were collected on venous malformation location, developmental venous anomaly location, developmental venous anomaly drainage pattern, and metameric location of venous malformations and developmental venous anomalies. Categoric variables were compared using χ2 tests. RESULTS: Forty-two patients with venous malformations were included. The mean age was 38.1 ± 11.1 years, and 78.6% of patients were female. The prevalence of developmental venous anomalies in this patient population was 28.6%. The control population of 84 patients had a mean age of 40.0±5.9 years, and 78.6% of patients were female. The prevalence of developmental venous anomalies in this patient population was 9.5% (P=.01). In 83.3% of cases, developmental venous anomalies were ipsilateral to the venous malformation, and in 75% of cases, they involved the same metamere. CONCLUSIONS: Our case-control study demonstrated a significant association between brain developmental venous anomalies and superficial venous malformations. These findings suggest that there may be a similar pathophysiologic origin for these 2 entities.

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