TY - JOUR
T1 - Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer
AU - Patra, Chitta Ranjan
AU - Bhattacharya, Resham
AU - Mukhopadhyay, Debabrata
AU - Mukherjee, Priyabrata
N1 - Funding Information:
This work was partly supported by CA136494, CA135011 to PM.
PY - 2010/3/8
Y1 - 2010/3/8
N2 - The targeted delivery of a drug should result in enhanced therapeutic efficacy with low to minimal side effects. This is a widely accepted concept, but limited in application due to lack of available technologies and process of validation. Biomedical nanotechnology can play an important role in this respect. Biomedical nanotechnology is a burgeoning field with myriads of opportunities and possibilities for advancing medical science and disease treatment. Cancer nanotechnology (1-100 nm size range) is expected to change the very foundations of cancer treatment, diagnosis and detection. Nanomaterials, especially gold nanoparticles (AuNPs) have unique physico-chemical properties, such as ultra small size, large surface area to mass ratio, and high surface reactivity, presence of surface plasmon resonance (SPR) bands, biocompatibility and ease of surface functionalization. In this review, we will discuss how the unique physico-chemical properties of gold nanoparticles may be utilized for targeted drug delivery in pancreatic cancer leading to increased efficacy of traditional chemotherapeutics.
AB - The targeted delivery of a drug should result in enhanced therapeutic efficacy with low to minimal side effects. This is a widely accepted concept, but limited in application due to lack of available technologies and process of validation. Biomedical nanotechnology can play an important role in this respect. Biomedical nanotechnology is a burgeoning field with myriads of opportunities and possibilities for advancing medical science and disease treatment. Cancer nanotechnology (1-100 nm size range) is expected to change the very foundations of cancer treatment, diagnosis and detection. Nanomaterials, especially gold nanoparticles (AuNPs) have unique physico-chemical properties, such as ultra small size, large surface area to mass ratio, and high surface reactivity, presence of surface plasmon resonance (SPR) bands, biocompatibility and ease of surface functionalization. In this review, we will discuss how the unique physico-chemical properties of gold nanoparticles may be utilized for targeted drug delivery in pancreatic cancer leading to increased efficacy of traditional chemotherapeutics.
KW - Anti-cancer drugs
KW - AuNPs
KW - Colloidal gold nanoparticles
KW - Drug delivery
KW - EGFR
KW - Fabrication
KW - Gold nanoparticles
KW - Pancreatic cancer
KW - Targeted therapy
KW - Tyrosine kinase
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U2 - 10.1016/j.addr.2009.11.007
DO - 10.1016/j.addr.2009.11.007
M3 - Review article
C2 - 19914317
AN - SCOPUS:76849117309
SN - 0169-409X
VL - 62
SP - 346
EP - 361
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 3
ER -