Extracellular vesicle-based drug delivery systems for cancer treatment

Sierra Walker; Sara Busatto; Anthony Pham; Ming Tian; Annie Suh; Kelsey Carson; Astrid Quintero; Maria Lafrence; Hanna Malik; Moises X. Santana; Joy Wolfram

doi:10.7150/thno.37097

Extracellular vesicle-based drug delivery systems for cancer treatment

Sierra Walker, Sara Busatto, Anthony Pham, Ming Tian, Annie Suh, Kelsey Carson, Astrid Quintero, Maria Lafrence, Hanna Malik, Moises X. Santana, Joy Wolfram

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play important roles in many physiological and pathological processes. EVs enable intercellular communication by serving as delivery vehicles for a wide range of endogenous cargo molecules, such as RNAs, proteins, carbohydrates, and lipids. EVs have also been found to display tissue tropism mediated by surface molecules, such as integrins and glycans, making them promising for drug delivery applications. Various methods can be used to load therapeutic agents into EVs, and additional modification strategies have been employed to prolong circulation and improve targeting. This review gives an overview of EV-based drug delivery strategies in cancer therapy.

Original language	English (US)
Pages (from-to)	8001-8017
Number of pages	17
Journal	Theranostics
Volume	9
Issue number	26
DOIs	https://doi.org/10.7150/thno.37097
State	Published - 2019

Keywords

Cancer therapy
Drug delivery
Extracellular vesicle
Nanomedicine

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.7150/thno.37097

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AU - Busatto, Sara

AU - Pham, Anthony

AU - Tian, Ming

AU - Suh, Annie

AU - Carson, Kelsey

AU - Quintero, Astrid

AU - Lafrence, Maria

AU - Malik, Hanna

AU - Santana, Moises X.

AU - Wolfram, Joy

N1 - Publisher Copyright: © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PY - 2019

Y1 - 2019

N2 - Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play important roles in many physiological and pathological processes. EVs enable intercellular communication by serving as delivery vehicles for a wide range of endogenous cargo molecules, such as RNAs, proteins, carbohydrates, and lipids. EVs have also been found to display tissue tropism mediated by surface molecules, such as integrins and glycans, making them promising for drug delivery applications. Various methods can be used to load therapeutic agents into EVs, and additional modification strategies have been employed to prolong circulation and improve targeting. This review gives an overview of EV-based drug delivery strategies in cancer therapy.

AB - Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play important roles in many physiological and pathological processes. EVs enable intercellular communication by serving as delivery vehicles for a wide range of endogenous cargo molecules, such as RNAs, proteins, carbohydrates, and lipids. EVs have also been found to display tissue tropism mediated by surface molecules, such as integrins and glycans, making them promising for drug delivery applications. Various methods can be used to load therapeutic agents into EVs, and additional modification strategies have been employed to prolong circulation and improve targeting. This review gives an overview of EV-based drug delivery strategies in cancer therapy.

KW - Cancer therapy

KW - Drug delivery

KW - Extracellular vesicle

KW - Nanomedicine

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Extracellular vesicle-based drug delivery systems for cancer treatment

Abstract

Keywords

ASJC Scopus subject areas

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