Extending human healthspan and longevity: a symposium report

Loren M. DeVito, Nir Barzilai, Ana Maria Cuervo, Laura J. Niedernhofer, Sofiya Milman, Morgan Levine, Daniel Promislow, Luigi Ferrucci, George A. Kuchel, Joan Mannick, Jamie Justice, Mitzi M. Gonzales, James L. Kirkland, Pinchas Cohen, Judith Campisi

Research output: Contribution to journalArticlepeer-review

Abstract

For many years, it was believed that the aging process was inevitable and that age-related diseases could not be prevented or reversed. The geroscience hypothesis, however, posits that aging is, in fact, malleable and, by targeting the hallmarks of biological aging, it is indeed possible to alleviate age-related diseases and dysfunction and extend longevity. This field of geroscience thus aims to prevent the development of multiple disorders with age, thereby extending healthspan, with the reduction of morbidity toward the end of life. Experts in the field have made remarkable advancements in understanding the mechanisms underlying biological aging and identified ways to target aging pathways using both novel agents and repurposed therapies. While geroscience researchers currently face significant barriers in bringing therapies through clinical development, proof-of-concept studies, as well as early-stage clinical trials, are underway to assess the feasibility of drug evaluation and lay a regulatory foundation for future FDA approvals in the future.

Original languageEnglish (US)
Pages (from-to)70-83
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1507
Issue number1
DOIs
StatePublished - Jan 2022

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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