Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma

Don L. Gibbons, Wei Lin, Chad J. Creighton, Shuling Zheng, Dror Berel, Yanan Yang, Maria Gabriela Raso, Diane D. Liu, Ignacio I. Wistuba, Guillermina Lozano, Jonathan M. Kurie

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Background: Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood. Methodology/Principal Findings: Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature. Conclusions/Significance: These findings provide evidence that K-rasG12D; p53R172H mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents.

Original languageEnglish (US)
Article numbere5401
JournalPloS one
Volume4
Issue number4
DOIs
StatePublished - Apr 30 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Gibbons, D. L., Lin, W., Creighton, C. J., Zheng, S., Berel, D., Yang, Y., Raso, M. G., Liu, D. D., Wistuba, I. I., Lozano, G., & Kurie, J. M. (2009). Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PloS one, 4(4), [e5401]. https://doi.org/10.1371/journal.pone.0005401