Expression of murine CD1 on gastrointestinal epithelium

P. A. Bleicher, S. P. Balk, S. J. Hagen, R. S. Blumberg, Thomas J Flotte, C. Terhorst

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

Cluster of differentiation 1 (CD1) in humans is a family of major histocompatibility complex (MHC) class I-like molecules expressed on the surface of immature thymocytes, Langerhans cells, and a supopulation of B cells. The only function identified for human CD1 is as a ligand recognized by a subpopulation of T lymphocytes. In order to study the distribution and function of these molecules in the mouse, a murine CD1 complementary DNA was expressed in mouse fibroblasts and used to produce monoclonal antibodies. These antibodies revealed prominent expression of murine CD1 only on gastrointestinal tract epithelium and in the cytoplasm of hepatocytes. Low levels of expression were also detected on thymocytes and peripheral lymphocytes. The gastrointestinal distribution of murine CD1 suggests that this molecule may be important in epithelial immunity.

Original languageEnglish (US)
Pages (from-to)679-682
Number of pages4
JournalScience
Volume250
Issue number4981
StatePublished - 1990
Externally publishedYes

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Thymocytes
Epithelium
Langerhans Cells
Major Histocompatibility Complex
Gastrointestinal Tract
Hepatocytes
Immunity
Cytoplasm
B-Lymphocytes
Complementary DNA
Fibroblasts
Monoclonal Antibodies
Lymphocytes
Ligands
T-Lymphocytes
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Bleicher, P. A., Balk, S. P., Hagen, S. J., Blumberg, R. S., Flotte, T. J., & Terhorst, C. (1990). Expression of murine CD1 on gastrointestinal epithelium. Science, 250(4981), 679-682.

Expression of murine CD1 on gastrointestinal epithelium. / Bleicher, P. A.; Balk, S. P.; Hagen, S. J.; Blumberg, R. S.; Flotte, Thomas J; Terhorst, C.

In: Science, Vol. 250, No. 4981, 1990, p. 679-682.

Research output: Contribution to journalArticle

Bleicher, PA, Balk, SP, Hagen, SJ, Blumberg, RS, Flotte, TJ & Terhorst, C 1990, 'Expression of murine CD1 on gastrointestinal epithelium', Science, vol. 250, no. 4981, pp. 679-682.
Bleicher PA, Balk SP, Hagen SJ, Blumberg RS, Flotte TJ, Terhorst C. Expression of murine CD1 on gastrointestinal epithelium. Science. 1990;250(4981):679-682.
Bleicher, P. A. ; Balk, S. P. ; Hagen, S. J. ; Blumberg, R. S. ; Flotte, Thomas J ; Terhorst, C. / Expression of murine CD1 on gastrointestinal epithelium. In: Science. 1990 ; Vol. 250, No. 4981. pp. 679-682.
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