Expression of 65‐kd heat shock proteins in the inflammatory myopathies

Reinhard Hohlfeld, Andrew G. Engel

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

In normal muscle, 65‐kd heat shock proteins (hsp) were detected on capillary endothelial cells, the mural elements of larger vessels, and some intracellular organelles, probably mitochondria. In the inflammatory myopathies, the 65‐kd hsp were detected on inflammatory cells, degenerating and regenerating fibers, and on many but not all nonnecrotic muscle fibers invaded by T cells. The expression of the 65‐kd hsp may be an immunenonspecific response to cellular “stress” but hsp determinants could possibly also serve as autoantigen(s) recognized by autoreactive T cells.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalAnnals of neurology
Volume32
Issue number6
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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