Expression and function of hla-dq8 (dqa1*0301/dqb1*0302) genes in transgenic mice

S. Cheng, J. Baisch, C. Krco, S. Savarirayan, J. Hanson, K. Hodgson, M. Smart, C. David

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Transgenic mice expressing HLA-DQA1*0301 and HLA-DQB1*0302 genes (DQ8) were produced. The transgenes were then transferred into mouse (Ab°) class II negative mice: the only class II molecules expressed in these animals were therefore coded by the HLA-DQ8 genes. Good expression of HLA-DQ molecules was found. Both CD4+ T cells and DQ8-specific T-cell receptor Vβ expressing cells were positively selected in these mice. The HLA-DQ8 molecules expressed in these animals can present various foreign and self antigens and induce T-cell proliferation in vitro. These mice will be invaluable in future studies of the structure and function of HLA-DQ8 genes.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalInternational Journal of Immunogenetics
Volume23
Issue number1
DOIs
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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