Abstract
Transgenic mice expressing HLA-DQA1*0301 and HLA-DQB1*0302 genes (DQ8) were produced. The transgenes were then transferred into mouse (Ab°) class II negative mice: the only class II molecules expressed in these animals were therefore coded by the HLA-DQ8 genes. Good expression of HLA-DQ molecules was found. Both CD4+ T cells and DQ8-specific T-cell receptor Vβ expressing cells were positively selected in these mice. The HLA-DQ8 molecules expressed in these animals can present various foreign and self antigens and induce T-cell proliferation in vitro. These mice will be invaluable in future studies of the structure and function of HLA-DQ8 genes.
Original language | English (US) |
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Pages (from-to) | 15-20 |
Number of pages | 6 |
Journal | International Journal of Immunogenetics |
Volume | 23 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1996 |
ASJC Scopus subject areas
- Immunology
- Molecular Biology
- Genetics
- Genetics(clinical)