Expanding the Utilization of Kidneys from Donors with Acute Kidney Injury

Caroline C. Jadlowiec, Raymond Lackner Heilman, Margaret S. Ryan, K. Sudhakar Reddy

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Our aim is to review the experience with transplanting kidneys from decreased donors with acute kidney injury (AKI). Recent Findings: The discard rate is higher for kidneys from AKI donors. Studies have uniformly shown that the risk of delayed graft function (DGF) is higher. However, the majority of studies have shown that other outcomes including short and long graft survival, eGFR, and risk of rejection are not inferior with transplanting AKI donor kidneys. To select AKI donor kidneys, we depend on preimplantation biopsy to exclude AKI kidneys with > 10% cortical necrosis or more than mild chronic changes. Although the DGF rate is higher, we have been able to safely discharge patients by POD 2 and manage DGF as an outpatient. Summary: It is estimated that if the transplant community used appropriately selected kidneys from AKI donors, there would be almost 600 additional transplants done each year in the US.

Original languageEnglish (US)
Pages (from-to)154-162
Number of pages9
JournalCurrent Transplantation Reports
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2020

Keywords

  • Deceased donor kidney transplantation
  • Deceased donors with acute kidney injury
  • Delayed graft function in kidney transplantation

ASJC Scopus subject areas

  • Transplantation
  • Surgery
  • Hepatology
  • Nephrology
  • Immunology

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