Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Anatoliy I. Masyuk; Tatyana V. Masyuk; Nicholas F. Larusso

doi:10.1016/j.jhep.2013.03.028

Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Anatoliy I. Masyuk, Tatyana V. Masyuk, Nicholas F. Larusso

Gastroenterology and Hepatology

Research output: Contribution to journal › Comment/debate › peer-review

148 Scopus citations

Abstract

Exosomes are small (30-100 nm in diameter) extracellular membrane-enclosed vesicles released by different cell types into the extracellular space or into biological fluids by exocytosis as a result of fusion of intracellular multivesicular bodies with the plasma membrane. The primary function of exosomes is intercellular communication with both beneficial (physiological) and harmful (pathological) potential outcomes. Liver cells are exosome-releasing cells as well as targets for endogenous exosomes and exosomes derived from cells of other organs. Despite limited studies on liver exosomes, initial observations suggest that these vesicles are important in liver physiology and pathophysiology. In this review, we briefly summarize the recent findings on liver exosomes, their functions and significance for novel diagnostic and therapeutic approaches.

Original language	English (US)
Pages (from-to)	621-625
Number of pages	5
Journal	Journal of hepatology
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/j.jhep.2013.03.028
State	Published - Sep 2013

Keywords

Biomarkers
Exosomes
Liver diseases
Therapeutics

ASJC Scopus subject areas

Hepatology

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10.1016/j.jhep.2013.03.028

Cite this

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title = "Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases",

abstract = "Exosomes are small (30-100 nm in diameter) extracellular membrane-enclosed vesicles released by different cell types into the extracellular space or into biological fluids by exocytosis as a result of fusion of intracellular multivesicular bodies with the plasma membrane. The primary function of exosomes is intercellular communication with both beneficial (physiological) and harmful (pathological) potential outcomes. Liver cells are exosome-releasing cells as well as targets for endogenous exosomes and exosomes derived from cells of other organs. Despite limited studies on liver exosomes, initial observations suggest that these vesicles are important in liver physiology and pathophysiology. In this review, we briefly summarize the recent findings on liver exosomes, their functions and significance for novel diagnostic and therapeutic approaches.",

keywords = "Biomarkers, Exosomes, Liver diseases, Therapeutics",

author = "Masyuk, {Anatoliy I.} and Masyuk, {Tatyana V.} and Larusso, {Nicholas F.}",

note = "Funding Information: This work was supported by the National Institutes of Health ( DK24031 and DK57993 for NFL), by the Mayo Clinic Center for Cell Signaling in Gastroenterology ( P30DK084567 ), and by the Mayo Foundation . ",

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AU - Masyuk, Tatyana V.

AU - Larusso, Nicholas F.

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N2 - Exosomes are small (30-100 nm in diameter) extracellular membrane-enclosed vesicles released by different cell types into the extracellular space or into biological fluids by exocytosis as a result of fusion of intracellular multivesicular bodies with the plasma membrane. The primary function of exosomes is intercellular communication with both beneficial (physiological) and harmful (pathological) potential outcomes. Liver cells are exosome-releasing cells as well as targets for endogenous exosomes and exosomes derived from cells of other organs. Despite limited studies on liver exosomes, initial observations suggest that these vesicles are important in liver physiology and pathophysiology. In this review, we briefly summarize the recent findings on liver exosomes, their functions and significance for novel diagnostic and therapeutic approaches.

AB - Exosomes are small (30-100 nm in diameter) extracellular membrane-enclosed vesicles released by different cell types into the extracellular space or into biological fluids by exocytosis as a result of fusion of intracellular multivesicular bodies with the plasma membrane. The primary function of exosomes is intercellular communication with both beneficial (physiological) and harmful (pathological) potential outcomes. Liver cells are exosome-releasing cells as well as targets for endogenous exosomes and exosomes derived from cells of other organs. Despite limited studies on liver exosomes, initial observations suggest that these vesicles are important in liver physiology and pathophysiology. In this review, we briefly summarize the recent findings on liver exosomes, their functions and significance for novel diagnostic and therapeutic approaches.

KW - Biomarkers

KW - Exosomes

KW - Liver diseases

KW - Therapeutics

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JO - Journal of hepatology

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Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Abstract

Keywords

ASJC Scopus subject areas

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