Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Anatoliy I. Masyuk, Tatyana V. Masyuk, Nicholas F. Larusso

Research output: Contribution to journalComment/debate

115 Scopus citations

Abstract

Exosomes are small (30-100 nm in diameter) extracellular membrane-enclosed vesicles released by different cell types into the extracellular space or into biological fluids by exocytosis as a result of fusion of intracellular multivesicular bodies with the plasma membrane. The primary function of exosomes is intercellular communication with both beneficial (physiological) and harmful (pathological) potential outcomes. Liver cells are exosome-releasing cells as well as targets for endogenous exosomes and exosomes derived from cells of other organs. Despite limited studies on liver exosomes, initial observations suggest that these vesicles are important in liver physiology and pathophysiology. In this review, we briefly summarize the recent findings on liver exosomes, their functions and significance for novel diagnostic and therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)621-625
Number of pages5
JournalJournal of hepatology
Volume59
Issue number3
DOIs
StatePublished - Sep 2013

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Keywords

  • Biomarkers
  • Exosomes
  • Liver diseases
  • Therapeutics

ASJC Scopus subject areas

  • Hepatology

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