Evolutionary dynamics of two related malignant plasma cell lines

David M Dingli, Bonnie K. Arendt, Željko Bajzer, Diane F Jelinek

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cancer is the consequence of sequential acquisition of mutations within somatic cells. Mutations alter the relative reproductive fitness of cells, enabling the population to evolve in time as a consequence of selection. Cancer therapy itself can select for or against specific subclones. Given the large population of tumor cells, subclones inevitably emerge and their fate will depend on the evolutionary dynamics that define the interactions between such clones. Using a combination of in vitro studies and mathematical modeling, we describe the dynamic behavior of two cell lines isolated from the same patient at different time points of disease progression and show how the two clones relate to one another. We provide evidence that the two clones coexisted at the time of initial presentation. The dominant clone presented with biopsy proven cardiac AL amyloidosis. Initial therapy selected for the second clone that expanded leading to a change in the diagnosis to multiple myeloma. The evolutionary dynamics relating the two cell lines are discussed and a hypothesis is generated in regard to the mechanism of one of the phenotypic characteristics that is shared by these two cell lines.

Original languageEnglish (US)
Pages (from-to)3792-3797
Number of pages6
JournalCell Cycle
Volume9
Issue number18
DOIs
StatePublished - Sep 15 2010

Fingerprint

Plasma Cells
Clone Cells
Cell Line
Genetic Fitness
Neoplasms
Mutation
Amyloidosis
Multiple Myeloma
Population
Disease Progression
Biopsy
Therapeutics

Keywords

  • Amyloidosis
  • Chemotherapy
  • Clonal evolution
  • Multiple myeloma
  • Selection

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Evolutionary dynamics of two related malignant plasma cell lines. / Dingli, David M; Arendt, Bonnie K.; Bajzer, Željko; Jelinek, Diane F.

In: Cell Cycle, Vol. 9, No. 18, 15.09.2010, p. 3792-3797.

Research output: Contribution to journalArticle

Dingli, David M ; Arendt, Bonnie K. ; Bajzer, Željko ; Jelinek, Diane F. / Evolutionary dynamics of two related malignant plasma cell lines. In: Cell Cycle. 2010 ; Vol. 9, No. 18. pp. 3792-3797.
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