Evidence of Surgical Management of Duodenal Cancer

Rory Smoot, Florencia Que

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Duodenal adenocarcinoma represents the most common histologic subtype of duodenal neoplasm, but remains rare overall. Risk factors for the development of duodenal adenocarcinoma include genetic predisposition, such as familial adenomatous polyposis (FAP) and other polyposis syndromes, as well as duodenal villous adenomas. Operative resection is the mainstay of curative therapy, and operative approaches include pancreatoduodenectomy and segmental duodenal resection depending on the location of the tumor within the duodenum. Prognostic factors after curative resection include lymph node metastases, positive lymph node ratio, and perineural invasion. The operative approach and tumor location within the duodenum have not impacted on prognosis. Data regarding the use of chemotherapy specifically in this neoplasm is limited, because these patients are often lumped together with other periampullary malignancies; however, no survival advantage has been demonstrated in limited adjuvant studies.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer, Cystic Neoplasms and Endocrine Tumors
Subtitle of host publicationDiagnosis and Management
PublisherWiley Blackwell
Pages194-196
Number of pages3
ISBN (Electronic)9781118307816
ISBN (Print)9780470673188
DOIs
StatePublished - Apr 7 2015

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Duodenal Neoplasms
Duodenum
Neoplasms
Adenocarcinoma
Lymph Nodes
Villous Adenoma
Adenomatous Polyposis Coli
Pancreaticoduodenectomy
Genetic Predisposition to Disease
Neoplasm Metastasis
Drug Therapy
Survival

Keywords

  • Adenocarcinoma
  • Adjuvant
  • Duodenum
  • Lymph node ratio
  • Pancreaticoduodenectomy
  • Perineural
  • Polyposis
  • Segmental resection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Smoot, R., & Que, F. (2015). Evidence of Surgical Management of Duodenal Cancer. In Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management (pp. 194-196). Wiley Blackwell. https://doi.org/10.1002/9781118307816.ch25

Evidence of Surgical Management of Duodenal Cancer. / Smoot, Rory; Que, Florencia.

Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management. Wiley Blackwell, 2015. p. 194-196.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smoot, R & Que, F 2015, Evidence of Surgical Management of Duodenal Cancer. in Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management. Wiley Blackwell, pp. 194-196. https://doi.org/10.1002/9781118307816.ch25
Smoot R, Que F. Evidence of Surgical Management of Duodenal Cancer. In Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management. Wiley Blackwell. 2015. p. 194-196 https://doi.org/10.1002/9781118307816.ch25
Smoot, Rory ; Que, Florencia. / Evidence of Surgical Management of Duodenal Cancer. Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management. Wiley Blackwell, 2015. pp. 194-196
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