Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Daniela M. Junqueira; Flavio S. Lopes; Fabiola C. De Souza; Syril Dorairaj; Tiago S. Prata

doi:10.2147/OPTH.S78743

Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Daniela M. Junqueira, Flavio S. Lopes, Fabiola C. De Souza, Syril Dorairaj, Tiago S. Prata

Ophthalmology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objective: This study evaluated the efficacy and safety of a new device (Eyedrop®) designed for eye drop instillation in patients with and without glaucoma. Methods: This prospective study included consecutive patients with glaucoma and healthy participants. After a complete eye examination and determination of baseline intraocular pressure (IOP), topical hypotensive medication was introduced in both eyes, and the Eyedrop® delivery device (a plastic device in which the bottle with eye drops is inserted) was made available to all participants (with video and written instructions) for use in one eye, randomly chosen. In the second phase, all patients were evaluated by an experienced examiner for IOP determination, investigation of possible associated side effects, and ease of instilling eye drops (by a visual analog scale [VAS]; 0–10). Results: Thirty two participants (mean age 42.3±16.2 years) were evaluated. Of these, 44% had glaucoma. There was no significant difference in mean IOP variation when comparing the eye using (-3.9±2.9 mmHg) or not using the device (-3.3±2.6 mmHg; P=0.36). The subjective rating of the facility of drops instillation was significantly higher with the Eyedrop® applicator (VAS =7.6±1.6) than without it (VAS =6.2±1.8; P<0.01), with a higher frequency of positive device-related evaluations (VAS score >5) among participants without prior experience with eye drop instillation (78.6% [11/14]) versus those already experienced (66.7% [12/18]). No difference in the frequency of side effects or in the distribution pattern of fluorescein between eyes was observed (P≥0.63). Conclusion: Eyedrop® received a better subjective response regarding the ease of instillation of hypotensive eye drops compared to traditional instillation, especially in patients with no previous experience with eye drops. Using the device did not result in any loss of hypotensive effect or increase in the frequency of side effects.

Original language	English (US)
Pages (from-to)	367-371
Number of pages	5
Journal	Clinical Ophthalmology
Volume	9
DOIs	https://doi.org/10.2147/OPTH.S78743
State	Published - Feb 23 2015

Keywords

Applicator
Eye drops
Glaucoma
Therapy adherence

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.2147/OPTH.S78743

Cite this

@article{bf110ddc2729456f818f9e7ec406c325,

title = "Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma",

abstract = "Objective: This study evaluated the efficacy and safety of a new device (Eyedrop{\textregistered}) designed for eye drop instillation in patients with and without glaucoma. Methods: This prospective study included consecutive patients with glaucoma and healthy participants. After a complete eye examination and determination of baseline intraocular pressure (IOP), topical hypotensive medication was introduced in both eyes, and the Eyedrop{\textregistered} delivery device (a plastic device in which the bottle with eye drops is inserted) was made available to all participants (with video and written instructions) for use in one eye, randomly chosen. In the second phase, all patients were evaluated by an experienced examiner for IOP determination, investigation of possible associated side effects, and ease of instilling eye drops (by a visual analog scale [VAS]; 0–10). Results: Thirty two participants (mean age 42.3±16.2 years) were evaluated. Of these, 44% had glaucoma. There was no significant difference in mean IOP variation when comparing the eye using (-3.9±2.9 mmHg) or not using the device (-3.3±2.6 mmHg; P=0.36). The subjective rating of the facility of drops instillation was significantly higher with the Eyedrop{\textregistered} applicator (VAS =7.6±1.6) than without it (VAS =6.2±1.8; P<0.01), with a higher frequency of positive device-related evaluations (VAS score >5) among participants without prior experience with eye drop instillation (78.6% [11/14]) versus those already experienced (66.7% [12/18]). No difference in the frequency of side effects or in the distribution pattern of fluorescein between eyes was observed (P≥0.63). Conclusion: Eyedrop{\textregistered} received a better subjective response regarding the ease of instillation of hypotensive eye drops compared to traditional instillation, especially in patients with no previous experience with eye drops. Using the device did not result in any loss of hypotensive effect or increase in the frequency of side effects.",

keywords = "Applicator, Eye drops, Glaucoma, Therapy adherence",

author = "Junqueira, {Daniela M.} and Lopes, {Flavio S.} and {De Souza}, {Fabiola C.} and Syril Dorairaj and Prata, {Tiago S.}",

note = "Publisher Copyright: {\textcopyright} 2015 Junqueira et al.",

year = "2015",

month = feb,

day = "23",

doi = "10.2147/OPTH.S78743",

language = "English (US)",

volume = "9",

pages = "367--371",

journal = "Clinical Ophthalmology",

issn = "1177-5467",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

AU - Junqueira, Daniela M.

AU - Lopes, Flavio S.

AU - De Souza, Fabiola C.

AU - Dorairaj, Syril

AU - Prata, Tiago S.

PY - 2015/2/23

Y1 - 2015/2/23

N2 - Objective: This study evaluated the efficacy and safety of a new device (Eyedrop®) designed for eye drop instillation in patients with and without glaucoma. Methods: This prospective study included consecutive patients with glaucoma and healthy participants. After a complete eye examination and determination of baseline intraocular pressure (IOP), topical hypotensive medication was introduced in both eyes, and the Eyedrop® delivery device (a plastic device in which the bottle with eye drops is inserted) was made available to all participants (with video and written instructions) for use in one eye, randomly chosen. In the second phase, all patients were evaluated by an experienced examiner for IOP determination, investigation of possible associated side effects, and ease of instilling eye drops (by a visual analog scale [VAS]; 0–10). Results: Thirty two participants (mean age 42.3±16.2 years) were evaluated. Of these, 44% had glaucoma. There was no significant difference in mean IOP variation when comparing the eye using (-3.9±2.9 mmHg) or not using the device (-3.3±2.6 mmHg; P=0.36). The subjective rating of the facility of drops instillation was significantly higher with the Eyedrop® applicator (VAS =7.6±1.6) than without it (VAS =6.2±1.8; P<0.01), with a higher frequency of positive device-related evaluations (VAS score >5) among participants without prior experience with eye drop instillation (78.6% [11/14]) versus those already experienced (66.7% [12/18]). No difference in the frequency of side effects or in the distribution pattern of fluorescein between eyes was observed (P≥0.63). Conclusion: Eyedrop® received a better subjective response regarding the ease of instillation of hypotensive eye drops compared to traditional instillation, especially in patients with no previous experience with eye drops. Using the device did not result in any loss of hypotensive effect or increase in the frequency of side effects.

AB - Objective: This study evaluated the efficacy and safety of a new device (Eyedrop®) designed for eye drop instillation in patients with and without glaucoma. Methods: This prospective study included consecutive patients with glaucoma and healthy participants. After a complete eye examination and determination of baseline intraocular pressure (IOP), topical hypotensive medication was introduced in both eyes, and the Eyedrop® delivery device (a plastic device in which the bottle with eye drops is inserted) was made available to all participants (with video and written instructions) for use in one eye, randomly chosen. In the second phase, all patients were evaluated by an experienced examiner for IOP determination, investigation of possible associated side effects, and ease of instilling eye drops (by a visual analog scale [VAS]; 0–10). Results: Thirty two participants (mean age 42.3±16.2 years) were evaluated. Of these, 44% had glaucoma. There was no significant difference in mean IOP variation when comparing the eye using (-3.9±2.9 mmHg) or not using the device (-3.3±2.6 mmHg; P=0.36). The subjective rating of the facility of drops instillation was significantly higher with the Eyedrop® applicator (VAS =7.6±1.6) than without it (VAS =6.2±1.8; P<0.01), with a higher frequency of positive device-related evaluations (VAS score >5) among participants without prior experience with eye drop instillation (78.6% [11/14]) versus those already experienced (66.7% [12/18]). No difference in the frequency of side effects or in the distribution pattern of fluorescein between eyes was observed (P≥0.63). Conclusion: Eyedrop® received a better subjective response regarding the ease of instillation of hypotensive eye drops compared to traditional instillation, especially in patients with no previous experience with eye drops. Using the device did not result in any loss of hypotensive effect or increase in the frequency of side effects.

KW - Applicator

KW - Eye drops

KW - Glaucoma

KW - Therapy adherence

UR - http://www.scopus.com/inward/record.url?scp=84923380145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923380145&partnerID=8YFLogxK

U2 - 10.2147/OPTH.S78743

DO - 10.2147/OPTH.S78743

M3 - Article

AN - SCOPUS:84923380145

SN - 1177-5467

VL - 9

SP - 367

EP - 371

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

ER -

Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this