Evaluation of the effects of severe depression on global cognitive function and memory

Shawn M. McClintock, C. Munro Cullum, Mustafa M. Husain, A. John Rush, Rebecca G. Knapp, Martina Mueller, Georgios Petrides, Shirlene Sampson, Charles H. Kellner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Introduction: Major depressive disorder (MDD) is thought to negatively impact cognitive function; however, the relationship has not been well explored. Objective: This study examined the association between depression severity and global cognitive function and memory in subjects with severe, treatment-resistant MDD. Methods: We enrolled 66 subjects with Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosed unipolar MDD in a multicenter trial to assess the efficacy and neurocognitive effects of electroconvulsive therapy (ECT). We measured depression severity with the 24 item Hamilton Rating Scale for Depression (HRSD24). Neuropsychologic measures included the Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and the Complex Figure Test (CFT). Correlational and regression analyses were conducted to explore associations between depression severity and cognitive function. Results: The mean age of the subjects was 53.6 years (SD=15.8), 65% were female, and mean HRSD24 was 33.9 (SD=6.7). Mean demographic-corrected T-scores for each neurocognitive measure were in the average to borderline range, and HRSD24 values were unrelated to performance on the MMSE, RAVLT immediate and delayed recall, and CFT immediate and delayed recall. Conclusion: In this sample of severely depressed subjects referred for ECT, depression severity was unrelated to global cognitive function or memory. Future research should examine the interactions between other depressive characteristics and neurocognitive function.

Original languageEnglish (US)
Pages (from-to)304-313
Number of pages10
JournalCNS Spectrums
Volume15
Issue number5
StatePublished - May 2010

Fingerprint

Cognition
Depression
Major Depressive Disorder
Verbal Learning
Electroconvulsive Therapy
Short-Term Memory
Treatment-Resistant Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Multicenter Studies
Regression Analysis
Demography
Interviews

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

McClintock, S. M., Cullum, C. M., Husain, M. M., Rush, A. J., Knapp, R. G., Mueller, M., ... Kellner, C. H. (2010). Evaluation of the effects of severe depression on global cognitive function and memory. CNS Spectrums, 15(5), 304-313.

Evaluation of the effects of severe depression on global cognitive function and memory. / McClintock, Shawn M.; Cullum, C. Munro; Husain, Mustafa M.; Rush, A. John; Knapp, Rebecca G.; Mueller, Martina; Petrides, Georgios; Sampson, Shirlene; Kellner, Charles H.

In: CNS Spectrums, Vol. 15, No. 5, 05.2010, p. 304-313.

Research output: Contribution to journalArticle

McClintock, SM, Cullum, CM, Husain, MM, Rush, AJ, Knapp, RG, Mueller, M, Petrides, G, Sampson, S & Kellner, CH 2010, 'Evaluation of the effects of severe depression on global cognitive function and memory', CNS Spectrums, vol. 15, no. 5, pp. 304-313.
McClintock SM, Cullum CM, Husain MM, Rush AJ, Knapp RG, Mueller M et al. Evaluation of the effects of severe depression on global cognitive function and memory. CNS Spectrums. 2010 May;15(5):304-313.
McClintock, Shawn M. ; Cullum, C. Munro ; Husain, Mustafa M. ; Rush, A. John ; Knapp, Rebecca G. ; Mueller, Martina ; Petrides, Georgios ; Sampson, Shirlene ; Kellner, Charles H. / Evaluation of the effects of severe depression on global cognitive function and memory. In: CNS Spectrums. 2010 ; Vol. 15, No. 5. pp. 304-313.
@article{f49c0afa119f4ec7b3a0bd0ffd7b8135,
title = "Evaluation of the effects of severe depression on global cognitive function and memory",
abstract = "Introduction: Major depressive disorder (MDD) is thought to negatively impact cognitive function; however, the relationship has not been well explored. Objective: This study examined the association between depression severity and global cognitive function and memory in subjects with severe, treatment-resistant MDD. Methods: We enrolled 66 subjects with Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosed unipolar MDD in a multicenter trial to assess the efficacy and neurocognitive effects of electroconvulsive therapy (ECT). We measured depression severity with the 24 item Hamilton Rating Scale for Depression (HRSD24). Neuropsychologic measures included the Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and the Complex Figure Test (CFT). Correlational and regression analyses were conducted to explore associations between depression severity and cognitive function. Results: The mean age of the subjects was 53.6 years (SD=15.8), 65{\%} were female, and mean HRSD24 was 33.9 (SD=6.7). Mean demographic-corrected T-scores for each neurocognitive measure were in the average to borderline range, and HRSD24 values were unrelated to performance on the MMSE, RAVLT immediate and delayed recall, and CFT immediate and delayed recall. Conclusion: In this sample of severely depressed subjects referred for ECT, depression severity was unrelated to global cognitive function or memory. Future research should examine the interactions between other depressive characteristics and neurocognitive function.",
author = "McClintock, {Shawn M.} and Cullum, {C. Munro} and Husain, {Mustafa M.} and Rush, {A. John} and Knapp, {Rebecca G.} and Martina Mueller and Georgios Petrides and Shirlene Sampson and Kellner, {Charles H.}",
year = "2010",
month = "5",
language = "English (US)",
volume = "15",
pages = "304--313",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "5",

}

TY - JOUR

T1 - Evaluation of the effects of severe depression on global cognitive function and memory

AU - McClintock, Shawn M.

AU - Cullum, C. Munro

AU - Husain, Mustafa M.

AU - Rush, A. John

AU - Knapp, Rebecca G.

AU - Mueller, Martina

AU - Petrides, Georgios

AU - Sampson, Shirlene

AU - Kellner, Charles H.

PY - 2010/5

Y1 - 2010/5

N2 - Introduction: Major depressive disorder (MDD) is thought to negatively impact cognitive function; however, the relationship has not been well explored. Objective: This study examined the association between depression severity and global cognitive function and memory in subjects with severe, treatment-resistant MDD. Methods: We enrolled 66 subjects with Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosed unipolar MDD in a multicenter trial to assess the efficacy and neurocognitive effects of electroconvulsive therapy (ECT). We measured depression severity with the 24 item Hamilton Rating Scale for Depression (HRSD24). Neuropsychologic measures included the Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and the Complex Figure Test (CFT). Correlational and regression analyses were conducted to explore associations between depression severity and cognitive function. Results: The mean age of the subjects was 53.6 years (SD=15.8), 65% were female, and mean HRSD24 was 33.9 (SD=6.7). Mean demographic-corrected T-scores for each neurocognitive measure were in the average to borderline range, and HRSD24 values were unrelated to performance on the MMSE, RAVLT immediate and delayed recall, and CFT immediate and delayed recall. Conclusion: In this sample of severely depressed subjects referred for ECT, depression severity was unrelated to global cognitive function or memory. Future research should examine the interactions between other depressive characteristics and neurocognitive function.

AB - Introduction: Major depressive disorder (MDD) is thought to negatively impact cognitive function; however, the relationship has not been well explored. Objective: This study examined the association between depression severity and global cognitive function and memory in subjects with severe, treatment-resistant MDD. Methods: We enrolled 66 subjects with Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosed unipolar MDD in a multicenter trial to assess the efficacy and neurocognitive effects of electroconvulsive therapy (ECT). We measured depression severity with the 24 item Hamilton Rating Scale for Depression (HRSD24). Neuropsychologic measures included the Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and the Complex Figure Test (CFT). Correlational and regression analyses were conducted to explore associations between depression severity and cognitive function. Results: The mean age of the subjects was 53.6 years (SD=15.8), 65% were female, and mean HRSD24 was 33.9 (SD=6.7). Mean demographic-corrected T-scores for each neurocognitive measure were in the average to borderline range, and HRSD24 values were unrelated to performance on the MMSE, RAVLT immediate and delayed recall, and CFT immediate and delayed recall. Conclusion: In this sample of severely depressed subjects referred for ECT, depression severity was unrelated to global cognitive function or memory. Future research should examine the interactions between other depressive characteristics and neurocognitive function.

UR - http://www.scopus.com/inward/record.url?scp=77952569893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952569893&partnerID=8YFLogxK

M3 - Article

C2 - 20448521

AN - SCOPUS:77952569893

VL - 15

SP - 304

EP - 313

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 5

ER -