Evaluation of damage in giant cell arteritis

for the Vasculitis Clinical Research Consortium

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives. To evaluate damage and variables associated with damage in GCA. Methods. Patients with GCA enrolled in a prospective, multicentre, longitudinal study were included. Perprotocol assessments were made with the Vasculitis Damage Index and the Large-Vessel Vasculitis Index of Damage. Results. The study included 204 patients: 156 women (76%), mean age at diagnosis 71.3 years (S.D. 8.3), mean follow-up of 3.5 years (S.D. 1.9). One or more damage item was present in 54% at baseline and 79% at the last follow-up on the Vasculitis Damage Index, and 60% at baseline and 82% at the last follow-up on the Large-Vessel Vasculitis Index of Damage. The most frequently observed damage items were largeartery complications (29% cohort) and ocular (22%). Among 117 patients with new damage, most new items were ocular (63 patients), cardiac/vascular (48) and musculoskeletal (34). Of these, treatment-associated items were frequently observed, including cataracts (46 patients), osteoporosis (22) and weight gain (22). Disease-associated new damage included ischaemic optic neuropathy (3 patients), limb claudication (13), arterial occlusions (10) and damage requiring vascular intervention (10). In univariate analysis, the risk of damage increased 22% for every additional year of disease duration [odds ratio (OR) 1.22 (95% CI 1.04, 1.45)]. In 94 patients enrolled within ≤90 days of diagnosis of GCA, the risk of new damage at the last follow-up decreased 30% for each additional relapse [OR 0.70 (95% CI 0.51, 0.97)]. Conclusions. Large-artery complications and ocular manifestations are the most commonly occurring items of damage in GCA. Most new damage is associated with treatment. These findings emphasize the cumulative burden of disease in GCA.

Original languageEnglish (US)
Article numberkex397
Pages (from-to)322-328
Number of pages7
JournalRheumatology (United Kingdom)
Volume57
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Giant Cell Arteritis
Vasculitis
Blood Vessels
Eye Manifestations
Odds Ratio
Ischemic Optic Neuropathy
Cataract
Osteoporosis
Multicenter Studies
Weight Gain
Longitudinal Studies
Extremities
Arteries
Recurrence
Therapeutics

Keywords

  • Damage
  • Giant cell arteritis
  • Large-artery manifestations
  • Large-vessel vasculitis
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

for the Vasculitis Clinical Research Consortium (2018). Evaluation of damage in giant cell arteritis. Rheumatology (United Kingdom), 57(2), 322-328. [kex397]. https://doi.org/10.1093/rheumatology/kex397

Evaluation of damage in giant cell arteritis. / for the Vasculitis Clinical Research Consortium.

In: Rheumatology (United Kingdom), Vol. 57, No. 2, kex397, 01.02.2018, p. 322-328.

Research output: Contribution to journalArticle

for the Vasculitis Clinical Research Consortium 2018, 'Evaluation of damage in giant cell arteritis', Rheumatology (United Kingdom), vol. 57, no. 2, kex397, pp. 322-328. https://doi.org/10.1093/rheumatology/kex397
for the Vasculitis Clinical Research Consortium. Evaluation of damage in giant cell arteritis. Rheumatology (United Kingdom). 2018 Feb 1;57(2):322-328. kex397. https://doi.org/10.1093/rheumatology/kex397
for the Vasculitis Clinical Research Consortium. / Evaluation of damage in giant cell arteritis. In: Rheumatology (United Kingdom). 2018 ; Vol. 57, No. 2. pp. 322-328.
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abstract = "Objectives. To evaluate damage and variables associated with damage in GCA. Methods. Patients with GCA enrolled in a prospective, multicentre, longitudinal study were included. Perprotocol assessments were made with the Vasculitis Damage Index and the Large-Vessel Vasculitis Index of Damage. Results. The study included 204 patients: 156 women (76{\%}), mean age at diagnosis 71.3 years (S.D. 8.3), mean follow-up of 3.5 years (S.D. 1.9). One or more damage item was present in 54{\%} at baseline and 79{\%} at the last follow-up on the Vasculitis Damage Index, and 60{\%} at baseline and 82{\%} at the last follow-up on the Large-Vessel Vasculitis Index of Damage. The most frequently observed damage items were largeartery complications (29{\%} cohort) and ocular (22{\%}). Among 117 patients with new damage, most new items were ocular (63 patients), cardiac/vascular (48) and musculoskeletal (34). Of these, treatment-associated items were frequently observed, including cataracts (46 patients), osteoporosis (22) and weight gain (22). Disease-associated new damage included ischaemic optic neuropathy (3 patients), limb claudication (13), arterial occlusions (10) and damage requiring vascular intervention (10). In univariate analysis, the risk of damage increased 22{\%} for every additional year of disease duration [odds ratio (OR) 1.22 (95{\%} CI 1.04, 1.45)]. In 94 patients enrolled within ≤90 days of diagnosis of GCA, the risk of new damage at the last follow-up decreased 30{\%} for each additional relapse [OR 0.70 (95{\%} CI 0.51, 0.97)]. Conclusions. Large-artery complications and ocular manifestations are the most commonly occurring items of damage in GCA. Most new damage is associated with treatment. These findings emphasize the cumulative burden of disease in GCA.",
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AU - Carette, Simon

AU - Hoffman, Gary S.

AU - Khalidi, Nader A.

AU - Koening, Curry L.

AU - Langford, Carol A.

AU - McAlear, Carol A.

AU - Monach, Paul A.

AU - Moreland, Larry

AU - Pagnoux, Christian

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N2 - Objectives. To evaluate damage and variables associated with damage in GCA. Methods. Patients with GCA enrolled in a prospective, multicentre, longitudinal study were included. Perprotocol assessments were made with the Vasculitis Damage Index and the Large-Vessel Vasculitis Index of Damage. Results. The study included 204 patients: 156 women (76%), mean age at diagnosis 71.3 years (S.D. 8.3), mean follow-up of 3.5 years (S.D. 1.9). One or more damage item was present in 54% at baseline and 79% at the last follow-up on the Vasculitis Damage Index, and 60% at baseline and 82% at the last follow-up on the Large-Vessel Vasculitis Index of Damage. The most frequently observed damage items were largeartery complications (29% cohort) and ocular (22%). Among 117 patients with new damage, most new items were ocular (63 patients), cardiac/vascular (48) and musculoskeletal (34). Of these, treatment-associated items were frequently observed, including cataracts (46 patients), osteoporosis (22) and weight gain (22). Disease-associated new damage included ischaemic optic neuropathy (3 patients), limb claudication (13), arterial occlusions (10) and damage requiring vascular intervention (10). In univariate analysis, the risk of damage increased 22% for every additional year of disease duration [odds ratio (OR) 1.22 (95% CI 1.04, 1.45)]. In 94 patients enrolled within ≤90 days of diagnosis of GCA, the risk of new damage at the last follow-up decreased 30% for each additional relapse [OR 0.70 (95% CI 0.51, 0.97)]. Conclusions. Large-artery complications and ocular manifestations are the most commonly occurring items of damage in GCA. Most new damage is associated with treatment. These findings emphasize the cumulative burden of disease in GCA.

AB - Objectives. To evaluate damage and variables associated with damage in GCA. Methods. Patients with GCA enrolled in a prospective, multicentre, longitudinal study were included. Perprotocol assessments were made with the Vasculitis Damage Index and the Large-Vessel Vasculitis Index of Damage. Results. The study included 204 patients: 156 women (76%), mean age at diagnosis 71.3 years (S.D. 8.3), mean follow-up of 3.5 years (S.D. 1.9). One or more damage item was present in 54% at baseline and 79% at the last follow-up on the Vasculitis Damage Index, and 60% at baseline and 82% at the last follow-up on the Large-Vessel Vasculitis Index of Damage. The most frequently observed damage items were largeartery complications (29% cohort) and ocular (22%). Among 117 patients with new damage, most new items were ocular (63 patients), cardiac/vascular (48) and musculoskeletal (34). Of these, treatment-associated items were frequently observed, including cataracts (46 patients), osteoporosis (22) and weight gain (22). Disease-associated new damage included ischaemic optic neuropathy (3 patients), limb claudication (13), arterial occlusions (10) and damage requiring vascular intervention (10). In univariate analysis, the risk of damage increased 22% for every additional year of disease duration [odds ratio (OR) 1.22 (95% CI 1.04, 1.45)]. In 94 patients enrolled within ≤90 days of diagnosis of GCA, the risk of new damage at the last follow-up decreased 30% for each additional relapse [OR 0.70 (95% CI 0.51, 0.97)]. Conclusions. Large-artery complications and ocular manifestations are the most commonly occurring items of damage in GCA. Most new damage is associated with treatment. These findings emphasize the cumulative burden of disease in GCA.

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