Abstract
Background and Aims Direct injection of chemotherapy into the portal vein for treatment of liver metastases may increase hepatic tissue levels while decreasing systemic levels and toxicities. We aimed to evaluate EUS-guided portal injection chemotherapy (EPIC) by using drug-eluting microbeads or nanoparticles and compare it with systemic injection. Methods We conducted a comparative feasibility trial in the acute porcine model (24 anesthetized pigs). Pigs were treated with irinotecan, doxorubicin, or albumin-bound paclitaxel nanoparticles (n = 8/group). Within each group, pigs were treated with EPIC or a systemic intravenous injection of drug and saline solution into the portal vein (n = 4/treatment). Irinotecan or doxorubicin were loaded onto microbeads for EPIC treatment only. We examined drug levels in tissue (1 hour) and plasma (15 minutes). Results EUS-guided access and injection was successful in all animals. EPIC with irinotecan-loaded microbeads showed nearly double the hepatic concentration compared with systemic injection (6242 vs 3692 ng/g) and almost half the systemic levels. EPIC with doxorubicin-loaded microbeads showed a 5-fold increase in hepatic levels (35,450 vs 6930 ng/g) and a 30-fold decrease in cardiac levels (153 vs 4805 ng/g) compared with systemic administration (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 444-446 |
| Number of pages | 3 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 83 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
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ASJC Scopus subject areas
- Gastroenterology
- Radiology Nuclear Medicine and imaging
Cite this
EUS-guided portal injection chemotherapy for treatment of hepatic metastases : Feasibility in the acute porcine model. / Faigel, Douglas Orrick; Lake, Douglas F.; Landreth, Tracy L.; Kelman, Catherine C.; Marler, Ronald J.
In: Gastrointestinal Endoscopy, Vol. 83, No. 2, 01.02.2016, p. 444-446.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - EUS-guided portal injection chemotherapy for treatment of hepatic metastases
T2 - Feasibility in the acute porcine model
AU - Faigel, Douglas Orrick
AU - Lake, Douglas F.
AU - Landreth, Tracy L.
AU - Kelman, Catherine C.
AU - Marler, Ronald J
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background and Aims Direct injection of chemotherapy into the portal vein for treatment of liver metastases may increase hepatic tissue levels while decreasing systemic levels and toxicities. We aimed to evaluate EUS-guided portal injection chemotherapy (EPIC) by using drug-eluting microbeads or nanoparticles and compare it with systemic injection. Methods We conducted a comparative feasibility trial in the acute porcine model (24 anesthetized pigs). Pigs were treated with irinotecan, doxorubicin, or albumin-bound paclitaxel nanoparticles (n = 8/group). Within each group, pigs were treated with EPIC or a systemic intravenous injection of drug and saline solution into the portal vein (n = 4/treatment). Irinotecan or doxorubicin were loaded onto microbeads for EPIC treatment only. We examined drug levels in tissue (1 hour) and plasma (15 minutes). Results EUS-guided access and injection was successful in all animals. EPIC with irinotecan-loaded microbeads showed nearly double the hepatic concentration compared with systemic injection (6242 vs 3692 ng/g) and almost half the systemic levels. EPIC with doxorubicin-loaded microbeads showed a 5-fold increase in hepatic levels (35,450 vs 6930 ng/g) and a 30-fold decrease in cardiac levels (153 vs 4805 ng/g) compared with systemic administration (P
AB - Background and Aims Direct injection of chemotherapy into the portal vein for treatment of liver metastases may increase hepatic tissue levels while decreasing systemic levels and toxicities. We aimed to evaluate EUS-guided portal injection chemotherapy (EPIC) by using drug-eluting microbeads or nanoparticles and compare it with systemic injection. Methods We conducted a comparative feasibility trial in the acute porcine model (24 anesthetized pigs). Pigs were treated with irinotecan, doxorubicin, or albumin-bound paclitaxel nanoparticles (n = 8/group). Within each group, pigs were treated with EPIC or a systemic intravenous injection of drug and saline solution into the portal vein (n = 4/treatment). Irinotecan or doxorubicin were loaded onto microbeads for EPIC treatment only. We examined drug levels in tissue (1 hour) and plasma (15 minutes). Results EUS-guided access and injection was successful in all animals. EPIC with irinotecan-loaded microbeads showed nearly double the hepatic concentration compared with systemic injection (6242 vs 3692 ng/g) and almost half the systemic levels. EPIC with doxorubicin-loaded microbeads showed a 5-fold increase in hepatic levels (35,450 vs 6930 ng/g) and a 30-fold decrease in cardiac levels (153 vs 4805 ng/g) compared with systemic administration (P
UR - http://www.scopus.com/inward/record.url?scp=84955208488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955208488&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2015.08.064
DO - 10.1016/j.gie.2015.08.064
M3 - Article
C2 - 26358330
AN - SCOPUS:84955208488
VL - 83
SP - 444
EP - 446
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 2
ER -