Etoposide-resistance in the multidrug-resistant LZ-8 cells

V. Liengswangwong, Michael Haddock, M. A. Sognier, J. A. Belli, J. A. Bonner

Research output: Contribution to journalArticle

Abstract

The multidrug-resistant LZ-8 cells were found to exhibit marked resistance to etoposide compared to wild-type, parental V79 cells. The multidrug resistant phenotype did not significantly contribute to this etoposide-resistance. Following exposure of LZ-8 cells and V79 cells to equivalent concentrations of etoposide, there was a dramatic reduction in the number of etoposide-induced stabilized DNA-topoisomerase II complexes in the LZ-8 cells compared to V79 cells, however, this reduction was not found when nuclei isolated from LZ-8 and V79 cells were exposed to equivalent concentrations of etoposide. These results suggest that cytoplasmic factors are involved in the etoposide-resistance of LZ-8 cells.

Original languageEnglish (US)
Pages (from-to)773-780
Number of pages8
JournalBiochemistry and Molecular Biology International
Volume34
Issue number4
StatePublished - 1994

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Multiple Drug Resistance
Etoposide
Type II DNA Topoisomerase
Phenotype

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Liengswangwong, V., Haddock, M., Sognier, M. A., Belli, J. A., & Bonner, J. A. (1994). Etoposide-resistance in the multidrug-resistant LZ-8 cells. Biochemistry and Molecular Biology International, 34(4), 773-780.

Etoposide-resistance in the multidrug-resistant LZ-8 cells. / Liengswangwong, V.; Haddock, Michael; Sognier, M. A.; Belli, J. A.; Bonner, J. A.

In: Biochemistry and Molecular Biology International, Vol. 34, No. 4, 1994, p. 773-780.

Research output: Contribution to journalArticle

Liengswangwong, V, Haddock, M, Sognier, MA, Belli, JA & Bonner, JA 1994, 'Etoposide-resistance in the multidrug-resistant LZ-8 cells', Biochemistry and Molecular Biology International, vol. 34, no. 4, pp. 773-780.
Liengswangwong, V. ; Haddock, Michael ; Sognier, M. A. ; Belli, J. A. ; Bonner, J. A. / Etoposide-resistance in the multidrug-resistant LZ-8 cells. In: Biochemistry and Molecular Biology International. 1994 ; Vol. 34, No. 4. pp. 773-780.
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