Ethnic, geographic, and genetic differences in arsenic metabolism at low arsenic exposure: A preliminary analysis in the multi-ethnic study of atherosclerosis (mesa)

Poojitha Balakrishnan, Miranda R. Jones, Dhananjay Vaidya, Maria Tellez-Plaza, Wendy S. Post, Joel D. Kaufman, Suzette J. Bielinski, Kent Taylor, Kevin Francesconi, Walter Goessler, Ana Navas-Acien

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Urinary arsenic species, including inorganic arsenic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (Ab), were measured using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) and corrected for organic sources from seafood consumption by regressing Ab on arsenic species using a validated method. Principal components of arsenic metabolism were also used as independent phenotypes. We conducted linear regression of arsenic traits with allelic dosage of candidate single nucleotide polymorphisms (SNPs) rs12768205 (G > A), rs3740394 (A > G), and rs3740393 (G > C) measured using Illumina MetaboChip. Models were stratified by non-Hispanic white vs. all other race/ethnicity and adjusted for age, sex, arsenic exposure, study site, and population stratification. Consistent with previous studies, rs12768205 showed evidence for strongest association (non-Hispanic white: iAs% −0.14 (P 0.83), MMA% −0.66 (0.49), DMA% 0.81(0.49); other race/ethnicity: 0.13 (0.71), −1.21 (0.09), 1.08 (0.20)). No association, however, passed the strict Bonferroni p-value. This was a novel study among an ethnically diverse population exposed to low arsenic levels.

Original languageEnglish (US)
Article number1179
JournalInternational journal of environmental research and public health
Volume15
Issue number6
DOIs
StatePublished - Jun 5 2018

Keywords

  • AS3MT
  • Arsenic
  • Epidemiology
  • Genetic susceptibility
  • Geography
  • MESA
  • Methylation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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