Estimation of myocardial blood flow for longitudinal studies with 13N-labeled ammonia and positron emission tomography

Timothy R DeGrado, Michael W. Hanson, Timothy G. Turkington, David M. Delong, Damian A. Brezinski, Jean Paul Vallée, Laurence W. Hedlund, Jian Zhang, Frederick Cobb, Martin J. Sullivan, R. Edward Coleman

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Although several modeling strategies have been developed and validated for quantification of myocardial blood flow (MBF) from 13N-labeled ammonia positron emission tomographic data, a comparison of noise characteristics of the various techniques in serial studies is lacking. Methods and Results: Dynamic 13N-labeled ammonia positron emission tomographic imaging was performed at baseline and after pharmacologic stress in (1) single studies of four dogs with concomitant measurement of microsphere blood flow and (2) initial and follow-up studies of eight normal volunteers. Data were obtained from short-axis images for the blood pool and myocardial regions corresponding to the three arterial vascular territories. Indexes of MBF were obtained by four distinct techniques: (1) University of California, Los Angeles, twocompartment model, (2) Michigan two-compartment model, and (3) a one-compartment model with variable blood volume term. Coronary flow reserve (CFR) was measured as the ratio of stress/rest MBF. The estimated standard deviation of the measurement error for the relative change between studies of rest and stress MBF and CFR was determined for each technique. Estimates of MBF from all techniques showed good correlation with microsphere blood flow (r=0.95 to 0.96) in canine myocardium. In human studies, similar mean estimates of MBF were found with all techniques. Techniques 1 and 3 showed the smallest interstudy variability in MBF and CFR. The estimated standard deviations for these techniques were approximately 20%, 30%, and 27% for rest MBF, stress MBF, and CFR, respectively. Conclusion: Noninvasive quantification of MBF and CFR from dynamic 13N-labeled ammonia positron emission tomography is most reproducible with technique 1 or 3. The ability to account for differences in myocardial partial volume gives preference to technique 3. However, substantial interstudy variability in regional MBF remains, suggesting the importance of procedural factors or real temporal fluctuations in MBF.

Original languageEnglish (US)
Pages (from-to)494-507
Number of pages14
JournalJournal of Nuclear Cardiology
Volume3
Issue number6
DOIs
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Ammonia
Positron-Emission Tomography
Longitudinal Studies
Microspheres
Electrons
Los Angeles
Regional Blood Flow
Blood Volume
Blood Vessels
Noise
Canidae
Myocardium
Healthy Volunteers
Dogs

Keywords

  • compartmental modeling
  • Myocardial blood flow
  • N-13 ammonia
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Estimation of myocardial blood flow for longitudinal studies with 13N-labeled ammonia and positron emission tomography. / DeGrado, Timothy R; Hanson, Michael W.; Turkington, Timothy G.; Delong, David M.; Brezinski, Damian A.; Vallée, Jean Paul; Hedlund, Laurence W.; Zhang, Jian; Cobb, Frederick; Sullivan, Martin J.; Coleman, R. Edward.

In: Journal of Nuclear Cardiology, Vol. 3, No. 6, 11.1996, p. 494-507.

Research output: Contribution to journalArticle

DeGrado, TR, Hanson, MW, Turkington, TG, Delong, DM, Brezinski, DA, Vallée, JP, Hedlund, LW, Zhang, J, Cobb, F, Sullivan, MJ & Coleman, RE 1996, 'Estimation of myocardial blood flow for longitudinal studies with 13N-labeled ammonia and positron emission tomography', Journal of Nuclear Cardiology, vol. 3, no. 6, pp. 494-507. https://doi.org/10.1016/S1071-3581(96)90059-8
DeGrado, Timothy R ; Hanson, Michael W. ; Turkington, Timothy G. ; Delong, David M. ; Brezinski, Damian A. ; Vallée, Jean Paul ; Hedlund, Laurence W. ; Zhang, Jian ; Cobb, Frederick ; Sullivan, Martin J. ; Coleman, R. Edward. / Estimation of myocardial blood flow for longitudinal studies with 13N-labeled ammonia and positron emission tomography. In: Journal of Nuclear Cardiology. 1996 ; Vol. 3, No. 6. pp. 494-507.
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abstract = "Background: Although several modeling strategies have been developed and validated for quantification of myocardial blood flow (MBF) from 13N-labeled ammonia positron emission tomographic data, a comparison of noise characteristics of the various techniques in serial studies is lacking. Methods and Results: Dynamic 13N-labeled ammonia positron emission tomographic imaging was performed at baseline and after pharmacologic stress in (1) single studies of four dogs with concomitant measurement of microsphere blood flow and (2) initial and follow-up studies of eight normal volunteers. Data were obtained from short-axis images for the blood pool and myocardial regions corresponding to the three arterial vascular territories. Indexes of MBF were obtained by four distinct techniques: (1) University of California, Los Angeles, twocompartment model, (2) Michigan two-compartment model, and (3) a one-compartment model with variable blood volume term. Coronary flow reserve (CFR) was measured as the ratio of stress/rest MBF. The estimated standard deviation of the measurement error for the relative change between studies of rest and stress MBF and CFR was determined for each technique. Estimates of MBF from all techniques showed good correlation with microsphere blood flow (r=0.95 to 0.96) in canine myocardium. In human studies, similar mean estimates of MBF were found with all techniques. Techniques 1 and 3 showed the smallest interstudy variability in MBF and CFR. The estimated standard deviations for these techniques were approximately 20{\%}, 30{\%}, and 27{\%} for rest MBF, stress MBF, and CFR, respectively. Conclusion: Noninvasive quantification of MBF and CFR from dynamic 13N-labeled ammonia positron emission tomography is most reproducible with technique 1 or 3. The ability to account for differences in myocardial partial volume gives preference to technique 3. However, substantial interstudy variability in regional MBF remains, suggesting the importance of procedural factors or real temporal fluctuations in MBF.",
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AU - Hanson, Michael W.

AU - Turkington, Timothy G.

AU - Delong, David M.

AU - Brezinski, Damian A.

AU - Vallée, Jean Paul

AU - Hedlund, Laurence W.

AU - Zhang, Jian

AU - Cobb, Frederick

AU - Sullivan, Martin J.

AU - Coleman, R. Edward

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N2 - Background: Although several modeling strategies have been developed and validated for quantification of myocardial blood flow (MBF) from 13N-labeled ammonia positron emission tomographic data, a comparison of noise characteristics of the various techniques in serial studies is lacking. Methods and Results: Dynamic 13N-labeled ammonia positron emission tomographic imaging was performed at baseline and after pharmacologic stress in (1) single studies of four dogs with concomitant measurement of microsphere blood flow and (2) initial and follow-up studies of eight normal volunteers. Data were obtained from short-axis images for the blood pool and myocardial regions corresponding to the three arterial vascular territories. Indexes of MBF were obtained by four distinct techniques: (1) University of California, Los Angeles, twocompartment model, (2) Michigan two-compartment model, and (3) a one-compartment model with variable blood volume term. Coronary flow reserve (CFR) was measured as the ratio of stress/rest MBF. The estimated standard deviation of the measurement error for the relative change between studies of rest and stress MBF and CFR was determined for each technique. Estimates of MBF from all techniques showed good correlation with microsphere blood flow (r=0.95 to 0.96) in canine myocardium. In human studies, similar mean estimates of MBF were found with all techniques. Techniques 1 and 3 showed the smallest interstudy variability in MBF and CFR. The estimated standard deviations for these techniques were approximately 20%, 30%, and 27% for rest MBF, stress MBF, and CFR, respectively. Conclusion: Noninvasive quantification of MBF and CFR from dynamic 13N-labeled ammonia positron emission tomography is most reproducible with technique 1 or 3. The ability to account for differences in myocardial partial volume gives preference to technique 3. However, substantial interstudy variability in regional MBF remains, suggesting the importance of procedural factors or real temporal fluctuations in MBF.

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