Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes

Noralane Morey Lindor, John Hopper, James Dowty

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The rapid clinical embrace of next generation multigene cancer predisposition panels has resulted in discovery of DNA variants in genes for which very limited data on penetrance has been published. Evidence for increased risks associated with these genes is often expressed in odds ratios and studies often were conducted on a priori high risk cohorts, i.e. those with young onset disease and/or positive family histories. Despite these limitations, one can estimate cumulative risks, which may be useful for health care providers who are counselling individuals on their results. We present cumulative risks for several under-studied genes and provide generic information that can be extrapolated to data still emerging.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalFamilial Cancer
DOIs
StateAccepted/In press - Mar 9 2016

Fingerprint

Breast Neoplasms
Genes
Penetrance
Health Personnel
Counseling
Odds Ratio
DNA
Neoplasms

Keywords

  • Cancer panels
  • Hazard ratios
  • Hereditary breast cancer
  • Nextgen
  • Odds ratios
  • Penetrance

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Oncology
  • Genetics(clinical)

Cite this

Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes. / Lindor, Noralane Morey; Hopper, John; Dowty, James.

In: Familial Cancer, 09.03.2016, p. 1-4.

Research output: Contribution to journalArticle

@article{80344463a97b475e8d16556e2ee431a3,
title = "Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes",
abstract = "The rapid clinical embrace of next generation multigene cancer predisposition panels has resulted in discovery of DNA variants in genes for which very limited data on penetrance has been published. Evidence for increased risks associated with these genes is often expressed in odds ratios and studies often were conducted on a priori high risk cohorts, i.e. those with young onset disease and/or positive family histories. Despite these limitations, one can estimate cumulative risks, which may be useful for health care providers who are counselling individuals on their results. We present cumulative risks for several under-studied genes and provide generic information that can be extrapolated to data still emerging.",
keywords = "Cancer panels, Hazard ratios, Hereditary breast cancer, Nextgen, Odds ratios, Penetrance",
author = "Lindor, {Noralane Morey} and John Hopper and James Dowty",
year = "2016",
month = "3",
day = "9",
doi = "10.1007/s10689-016-9896-2",
language = "English (US)",
pages = "1--4",
journal = "Familial Cancer",
issn = "1389-9600",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes

AU - Lindor, Noralane Morey

AU - Hopper, John

AU - Dowty, James

PY - 2016/3/9

Y1 - 2016/3/9

N2 - The rapid clinical embrace of next generation multigene cancer predisposition panels has resulted in discovery of DNA variants in genes for which very limited data on penetrance has been published. Evidence for increased risks associated with these genes is often expressed in odds ratios and studies often were conducted on a priori high risk cohorts, i.e. those with young onset disease and/or positive family histories. Despite these limitations, one can estimate cumulative risks, which may be useful for health care providers who are counselling individuals on their results. We present cumulative risks for several under-studied genes and provide generic information that can be extrapolated to data still emerging.

AB - The rapid clinical embrace of next generation multigene cancer predisposition panels has resulted in discovery of DNA variants in genes for which very limited data on penetrance has been published. Evidence for increased risks associated with these genes is often expressed in odds ratios and studies often were conducted on a priori high risk cohorts, i.e. those with young onset disease and/or positive family histories. Despite these limitations, one can estimate cumulative risks, which may be useful for health care providers who are counselling individuals on their results. We present cumulative risks for several under-studied genes and provide generic information that can be extrapolated to data still emerging.

KW - Cancer panels

KW - Hazard ratios

KW - Hereditary breast cancer

KW - Nextgen

KW - Odds ratios

KW - Penetrance

UR - http://www.scopus.com/inward/record.url?scp=84960131071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960131071&partnerID=8YFLogxK

U2 - 10.1007/s10689-016-9896-2

DO - 10.1007/s10689-016-9896-2

M3 - Article

C2 - 26960971

AN - SCOPUS:84960131071

SP - 1

EP - 4

JO - Familial Cancer

JF - Familial Cancer

SN - 1389-9600

ER -